This produces acetyl-CoA, which is released from the enzyme complex and subsequently enters the citric acid cycle. WikiMatrix In contrast to prenylation and myristoylation, palmitoylation is usually reversible (because the bond between palmitic acid and protein is often a thioester bond). WikiMatrix...
. CoA-bound substrates are found as intermediates in many cellularbiosynthesispathways, including β-oxidation and synthesis of fatty acids,steroid synthesis, mevalonate andketogenesispathways, and include molecules such as acetyl-CoA, malonyl-CoA, acetoacetyl-CoA, propionyl-CoA, and arachidonoyl-CoA....
They are served as important intermediates in a variety of biological process, such as acetyl-CoA is an acetyl donor in the citric acid cycle [2], and other thioesters are commonly involved in the synthesis of many substances inside cells, such as peptides, fatty acids, sterols, terpenes, ...
Depiction of the transport of CoA from the bulk to the active site and acetyl CoA back outside in the tunnel identified. Supplementary Data 1 Initial and final coordinates of the systems in the molecular dynamics simulations as pdb formatted files. Rights and permissions Reprints and permissions ...
The docking results of the ligand in the active site of the R domain showed that reductase side chains have a high affinity towards ligand binding, while the thioester oxygen of each substrate forms a hydrogen bond with the OH group of Tyr176 and the thiol group of the substrate is closer...
This produces acetyl-CoA, which is released from the enzyme complex and subsequently enters the citric acid cycle. WikiMatrix In contrast to prenylation and myristoylation, palmitoylation is usually reversible (because the bond between palmitic acid and protein is often a thioester bond). WikiMatrix...
In this study, two experimental approaches were used to identify the site of action of thioesterase II. (i) The two thioesterase I domains were removed from the fatty acid synthetase with trypsin. The modified multienzyme was incubated with [2- 14C]malonyl-CoA, acetyl-CoA, and NADPH to form...
The 1H nuclear magnetic resonance (1H-nmr) spectra of aqueous solutions of butyryl-CoA (Bu-CoA), indoleacetyl-CoA (IA-CoA), and phenylacetyl-CoA (PA-CoA) were examined at various concentrations and temperatures and compared to spectra of acetyl-CoA (Ac-CoA) and benzoyl-CoA (Bz-CoA) in ...