Acetyl-CoA: Acetyl-CoA is a specific type of Acyl-CoA in which the acyl group is a two-carbon acetyl group (-COCH3). The acetyl group is attached to coenzyme A via a thioester bond, similar to other Acyl-CoAs. Role in Metabolic Pathways: Acyl-CoA: Acyl-CoAs serve as key intermedia...
Acyl-CoA is a group of coenzymes that metabolize fatty acids. Acyl-CoA's are susceptible to beta oxidation, forming, ultimately, acetyl-CoA. The acetyl-CoA enters the citric acid cycle, eventually forming several equivalents of ATP. In this way, fats are converted to ATP, the universal ...
We identified malonylated acetyl-CoA carboxylase 1 (ACC1) as a core target of a KD-improved fatty liver. Importantly, the malonylation of ACC1 at Lys1523 enhanced its activity and stability, whereas both the protein level and malonylation of ACC1 were downregulated by KD intervention. Our ...
ForB. subtilisit was shown that AMP-forming acetyl-CoA (coenzyme A)-synthetase (AcsA) activity is regulated by acetylation of a lysine side chain (K549) in core region A10 of the C-terminal domain34,36,42. This lysine is conserved in AMP-forming acetyl-CoA synthetases and other acyl-AMP...
Leukotriene A-4 hydrolase TCDd-inducible poly (ADP-ribose) polymerase Dihydrolipoyl dehydrogenase, mitochondrial Cytosolic acyl CoA thioester hydrolase Cell division cycle–associated 7–like protein Translin Glycerol kinase Type II inositol 1,4,5-trisphosphate 5-phosphatase ...
The final product of the three stages of fatty acid degradation is Acetyl-CoA. This is ametabolismmolecule used to carry carbon atoms. The molecule is then fed into the citric acid cycle, an essential part of energy supply. The citric acid cycle is a series of chemical reactions usingoxygen...
Because the Xcc FabH protein has higher amino acid identities when compared to the straight-chain fatty acid producing bacterial FabHs, than to the BCFA producing bacterial FabHs, it would be expected that Xcc FabH would prefer acetyl-CoA as a primer to initiate straight-chain fatty acid ...
The acyl–ACP thioesterases (acyl-ACP TE; FatA, FatB) catalyze the FA chain termination through hydrolysis of the thioester bond of acyl–ACP to release the free FAs [9]. These free FAs are reactivated by a long-chain acyl-CoA synthetase (LACS) to form acyl-CoA esters and are exported...
It must be emphasised that under physiological conditions, the changes in PA intake do not significantly alter its tissue concentration, which is maintained by endogenous biosynthesis from acetyl-CoA catalysed by acetyl-CoA carboxylase and fatty acid synthase. The homeostatic balance of PA may be disr...
Acyl-coenzyme A (acyl-CoA) thioesters are evolutionarily conserved, compartmentalized, and energetically activated substrates for biochemical reactions. The ubiquitous involvement of acyl-CoA thioesters in metabolism, including the tricarboxylic acid cycle, fatty acid metabolism, amino acid degradation, and...