Purpose: This study aimed to investigate the expression of Acyl-CoA thioesterase 8 (ACOT8) in breast cancer (BC) and its association with clinicopathological characteristics, patient survival, and immune infiltration. Methods: We conducted a comprehensive analysis of ACOT8 mRNA differential...
产品名称ACOT8 Acyl-CoA Thioesterase 8 Human Recombinant Protein 产品描述ACOT8 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 342 amino acids (1-319) and having a molecular mass of 38.3kDa. ACOT8 is fused to a 23 amino acid His-tag at N-term...
Acyl-CoAthioesterase 3 (Acot3; PTE-Ia) is a peroxisomal enzyme that has only been characterized within the mouse[4]. Hunt and co-workers[4]demonstrated that the reduction in the number of peroxisomal Acots from four to two between the mouse and human genomes was a result of convergent evol...
In addition to the pathways illustrated, fatty acyl-CoAs can be degraded by thioesterases that cleave the FA:CoA bond, and by nudix hydrolases that cleave the pyrophosphate bond within the CoA moiety. The ACS reaction is ATP-dependent. In the first half-reaction, the FA substrate is ...
Distinct transcriptional regulation of long-chain acyl-CoA synthetase isoforms and cytosolic thioesterase 1 in the rodent heart by fatty acids and insulin The molecular mechanism(s) responsible for channeling long-chain fatty acids (LCFAs) into oxidative versus nonoxidative pathways is (are) poorly und...
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Acyl-CoA thioesterase 1 (Acot1), as an important enzyme in fatty acid metabolism, catalyzes the reaction of fatty acyl-CoAs to CoA-SH and free fatty acids11. Due to the high energy demand to supply circulating function, cardiomyocytes prefer fatty acids as metabolism substrates and possess mas...
OPEN Citation: Cell Death and Disease (2017) 8, e2793; doi:10.1038/cddis.2017.202 Official journal of the Cell Death Differentiation Association www.nature.com/cddis Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ–p53–p21 signaling pathway Seung Hee Jung1...
69–71 Only two human acyl-CoA thioesterases (ACOT4 and ACOT8 important in α- and β-oxidation of fatty acyl-CoAs, DCA, bile acid-CoAs, and methyl branched-CoAs to free fatty acid +CoA) and one human acyltransferase (peroxisomal bile acid-CoA:amino acid N-acyl...
free intramitochondrial AA is generated by the action of an acyl-coenzyme A (CoA) synthetase (ACSL4) and a mitochondrial acyl-CoA thioesterase (ACOT2). ACSL4 esterifies free AA to AA-CoA, which could be delivered to ACOT2 and, in turn, releases AA in the mitochondria upon hormone treat...