Acyl-CoA thioesters possess an electrophilic carbonyl-carbon and are able to undergo non-enzyme catalyzed transacylation reactions with biological nucleophiles leading to covalent binding to protein and drug-protein adduct formation. Such drug-protein adducts are proposed to mediate idiosyncratic drug ...
Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4alpha. Nature 1998;392:512-516.Hertz R, Magenhelm J, Berman I & Bar-Tana J 1998 Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α. Nature 392 512-516. (https://doi.org/10.1038/33185)...
Within the peroxisome, several ACOTs have been identified and characterized that cleave the thioester bond of acyl groups attached to coenzyme A (CoASH), to release the free acid and CoASH (Fig. 1). The acyl groups have been identified as long-, medium- and short-chain fatty acids, ...
Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. These enzymes are localized in almost all cellular compartm...
They catalyze the dehydrogenation of acyl-CoA thioesters to the corresponding trans -2-enoyl-CoA. This review examines the structure of medium chain acyl-CoA dehydrogenase, as a representative of the dehydrogenase family, with respect to the catalytic mechanism and its broad chain length specificity...
ACOT7 is a cytosolic acyl coenzyme A thioester hydrolase that primarily hydrolyzes the CoA thioester of palmitoyl-CoA. To determine whether or not ACOT7 depletion-mediated cytostasis is due to acyl-CoA thioesterase activity per se, we treated MCF7 cells with nordihydroguaiaretic acid (NDGA), ...
Fatty acyl-CoA thioesters are essential intermediates in lipid metabolism. For many years there have been numerous conflicting reports concerning the possibility that these compounds also serve regulatory functions. In this review, we examine the evidence that long-chain acyl-CoA is a regulatory signal...
The recently cloned human acyl-CoA-synthetase 5 (ACS5) is predominantly found in the small intestine and represents a key enzyme in providing cytosolic acyl-CoA thioesters. Protein synthesis and mRNA expression of ACS5 were studied in human intestinal tissues using different methods, including a ...
Long-chain-fatty-aid CoA ligases (EC 6.2.1.3) catalyse the bioactivation of fatty acids forming acyl-CoA thioesters that are then substrates for anabolic and catabolic pathways. In addition to these roles it is now recognised that fatty acyl-CoA esters are key regulatory molecules affecting numer...
Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor 4α Nature, 392 (1998), pp. 512-516 View in ScopusGoogle Scholar 13 N. Raman, P.N. Black, C. DiRusso Characterization of the fatty-acid responsive transcription factor FadR J. Biol. Chem., 272 (1997), pp. 30645-30650...