The irreversible Michael addition of thiols to acrylamides is reported as a new tool for the kinetic target-guided synthesis. In an unprecedented enzymatic hydrolysis/thio-Michael addition procedure, potent and selective acetylcholinesterase inhibitors are assembled by the enzyme using both its esterasic...
A novel and efficient methodology for thio-michael addition in the synthesis of cis-β-thio-α-aminoacid derivatives using Zn[ (l)-Pro]2as heterogeneous catalyst. ROCHA M P D,OLIVEIRA A R,ALBUQUERQUE T B,et al. RSC Adv . 2016Rocha, M. P. D.; Oliveira, A. R.; Albuquerque, T. ...
Results showed that thio-Michael addition is faster than aza-Michael addition due to higher nucleophilicity of thiolate anion in comparison with neutral amino functionality. Mild reaction condition, low catalyst/substrate ratio, high efficiently, and reusability make this new basic heterogeneous catalyst ...
The addition of a methyl group to the ring of quinoline in the sixth position leads to the activity loss. This can be explained by the strain energy growth (Table 3), which indicates the presence of strained contacts, which is unfavorable for protein–ligand complex formation and thus scoring...
Thiophosphoramide catalyzed asymmetric Michael addition of cyclopentanone to chalconesdoi:10.1016/j.tetasy.2011.02.015Thiophosphoramide 1b was found to be an effective bifunctional organocatalyst in the asymmetric Michael reaction of cyclopentanone to various chalcones, affording the corresponding adducts in ...
(1973), “Michael-type” Addition to Conjugated Ketene Thioacetals. Angew. Chem. Int. Ed. Engl., 12: 69–70. doi: 10.1002/anie.197300691 Author Information Fachbereich 14 Chemie, Institut für Organische Chemie der Universitiät 63 Giessen, Ludwigstrasse 21 (Germany) *Fachbereich 14 Chemie...
内容提示: ORIGINAL PAPERAsymmetric Michael addition of 1,3-bis(phenylthio)propan-2-oneto nitroalkenes employing Takemoto’s thiourea catalystSamira Ansari•Gerhard Raabe•Dieter EndersReceived: 23 November 2012/Accepted: 25 December 2012/Published online: 14 February 2013? Springer-Verlag Wien 2013...
A novel type of bidentate hydrogen bond donor catalysts based on (thio)phosphorodiamides catalophore has been developed for the asymmetric Michael addition of 2-hydroxy-1,4-naphthoquione to nitroolefins, affording the corresponding adducts in high yields with excellent level of enantioselectivities ...
摘要: The template 2‐deoxy‐1‐thio‐α‐hexopyranosid‐3‐ulose was synthesized in quantitative yield and high diastereoselectivity by 1,4‐addition of aryl and alkyl thiols to hex‐1‐en‐3‐ulose promoted by cesium carbonate in THF.
StateAidangStateLuStateYoumingStateWangStateGuipingStateWuStateWileyChemInformY. Liu, Y. Wu, A. Lu, Y. Wang, G. Wu, Z. Zhou, C. Tang, Thiophosphoramide catalyzed asymmetric Michael addition of cyclopentanone to chalcones. Tetrahedron Asymmetry 22(4), 476-479 (2011)...