The antihyperglycaemic effect and the possible mechanism of action of T-174, a novel thiazolidinedione derivative, was determined in vivo and in vitro. Oral administration of T-174 markedly improved hyperglycaemia, hyperinsulinaemia, hyperlipidaemia, and glucose intolerance in genetically obese and diabe...
Actions of novel antidiabetic thiazolidinedione, T-174, in animal models of non-insulin-dependent diabetes mellitus (NIDDM) and in cultured muscle cells 1 The antihyperglycaemic effect and the possible mechanism of action of T-174, a novel thiazolidinedione derivative, was determined in vivo and ...
In addition, the inhibition of prostaglandins production or the loss of their activity causes the degeneration of the endothelium in the blood vessel walls, platelet aggregation and the dysfunction of cellular mechanism in the smooth muscle, which leads to cardiovascular diseases. Among others, the ...
Studies have suggested that TZD-induced activation of PPAR-γ correlates with antidiabetic action, but the mechanism by which the activated PPAR-γ is involved in reducing insulin resistance is not known.Yuka FukuiSei=ichiro MasuiShiho Osada
Objective: To determine the inhibitory effect and mechanism of Notch signalling on adipogenesis of mouse adipose-derived stem cells (mASCs). Materials a... Y Huang,X Yang,Y Wu,... - 《Cell Proliferation》 被引量: 88发表: 2010年
Moreover, the agent caused oxidative stress associated with a strong induction of reactive oxygen species and hydrogen peroxide uptake inhibition by a mixed biofilm. In addition, S-8 altered symbiotic relationship between these species by a complex mechanism. Streptococcal genes associated with quorum ...
The commitment of MSCs during differentiation towards either adipogenesis or osteogenesis involves a stochastic mechanism under the control of lineage-specific transcription factors. Runt domain-containing protein, RUNX2 (also known as CBFA1 or OSF2), Osterix and msh homoeobox 2 (Msx2) play an ...
ACTIVITY : Antidiabetic; nephrotropic; hypoglycemic; hypolipidemic; hypotensive; antiarteriosclerotic; anabolic; anorectic.. MECHANISM OF ACTION : Not given.doi:EP1173437 A2BLACKLER PaulSmithKline Beecham PharmaceuticalsCRAIG AndrewSmithKline Beecham Pharmaceuticals...
Dan Hu,Chun-qi Wu,Ze-jun Li,Yue Liu,Xing Fan,Quan-jun Wang,Ri-gao Ding.Characterizing the mechanism of thiazolidinedione-induced hepatotoxicity: An in vitro model in mitochondria[J].Toxicology and Applied Pharmacology,2015 (2)Hu D, Wu CQ, Li ZJ, Liu Y, Fan X, Wang QJ,...
ACTIVITY : Antidiabetic; nephrotropic; hypoglycemic; hypolipidemic; hypotensive; antiarteriosclerotic; anabolic; anorectic.. MECHANISM OF ACTION : Not given.ポールデイビッドジェイムズブラックラーアンドリューサイモンクレイグロバートゴードンジャイルズ...