The left panel shows the mechanism of action of thiazide diuretics in the DCT. Two types of DCT cells have been identified; referred to here as DCT1 and DCT2. Na and Cl are reabsorbed across the apical membrane of DCT1 cells only via the thiazide-sensitive Na-Cl co-transporter. This ...
How does chlorothiazide work (mechanism of action)? Chlorothiazide works by increasing how much you pee. It does this by helping the kidneys remove electrolytes, such as sodium (salt), and water from the body. How is chlorothiazide supplied (dosage forms)?
It helps lower blood pressure by reducing the volume of fluid in the body through increased urine output. The mechanism of action in this context is similar to its diuretic effect. Storage Conditions: Store in a cool and dry place. View all 3.2 GHS Classification Signal: Danger GHS ...
Mechanism of action in hypertension Full details of the sites and mechanisms of action of diuretics on the kidney and their unwanted effects are considered inChapter 14. Actions involved in lowering BP include the following: ■ An initial hypotensive effect is produced by intravascular salt and wate...
The mechanism of action results in an interference with the renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosage, all thiazides are approximately equal in their diuretic potency. The mechanism whereby thiazides function in the control of hypertension is unknown. ...
Combination preparation comprises thiazide diuretic, preferably hydrochlorothiazide (5-50 mg) and a loop diuretic, preferably torseamide (2.5-15 mg), either in alone or combination, as active substances. ACTIVITY : Cardiant. MECHANISM OF ACTION : Angiotensin converting enzyme inhibitor; Angiotensin II...
Mechanism Of Action Metoprolol is a beta1-selective (cardioselective) adrenergic receptor blocker. This preferential effect is not absolute however, and at higher plasma concentrations, metoprolol also inhibits beta2adrenoreceptors, chiefly located in the bronchial andvascularmusculature. Metoprolol has no...
of patients with ADPKD with near-normal kidney functions and late-stage ADPKD2,3. However, tolvaptan usage has been implicated in polyuria, with an increase in urinary free water excretion related to the drug’s mechanism of action, and it has been established as a diuretic for treatment of ...
Mechanism of Action: Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Normally, the sodium-chloride symporter transports ...
Thiazide diuretics have been the mainstay of antihypertensive therapy for over 30 years. Their precise mechanism of antihypertensive action is still incomp... AG Dupont - 《Cardiovascular Drugs & Therapy》 被引量: 74发表: 1993年 Changing patterns of initial drug therapy for the treatment of hypert...