Mechanism of action The diuretic action of chlorothiazide, like other drugs of this series, is caused by reduced absorption of sodium and chloride ions by the kidneys during their simultaneous, intense excretion from the organism. Safety Profile Moderately_toxic by intraperitoneal and intravenous routes...
Mechanism of action in hypertension Full details of the sites and mechanisms of action of diuretics on the kidney and their unwanted effects are considered inChapter 14. Actions involved in lowering BP include the following: ■ An initial hypotensive effect is produced by intravascular salt and wate...
How does chlorothiazide work (mechanism of action)? Chlorothiazide works by increasing how much you pee. It does this by helping the kidneys remove electrolytes, such as sodium (salt), and water from the body. How is chlorothiazide supplied (dosage forms)?
Mechanism of Action Na and Water Transport in the Proximal Tubule DCT diuretics are related chemically to CA inhibitors, and most retain significant CA-inhibiting potential. As discussed above, CA inhibitors interfere indirectly with the activity of NHE3 in the proximal tubule. Although this effect ...
Solubilization and partial purification of the thiazide diuretic receptor from rabbit renal cortex like diuretic drug, binds to receptors in rat renal cortex closely related to the thiazide-sensitivee Na/Cl transport pathway of the renal distal tubule... DH Ellison,J Morrisey,GV Desir - Biochimica...
of patients with ADPKD with near-normal kidney functions and late-stage ADPKD2,3. However, tolvaptan usage has been implicated in polyuria, with an increase in urinary free water excretion related to the drug’s mechanism of action, and it has been established as a diuretic for treatment of ...
Mechanism of Action: Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Normally, the sodium-chloride symporter transports ...
(5 μM, 48 h), neuronal activity will be transformed from single individual firing into hypersynchronized bursting activity. What underlies such activity transformation is clearly a physiological question and may shed new light on the mechanism of activity-dependent neural plasticity. Interestingly, ...
The literature data suggest a positive effect of thiazide diuretic treatment on bone health both by increasing bone mineral density and by decreasing the r
Solubilization and partial purification of the thiazide diuretic receptor from rabbit renal cortex like diuretic drug, binds to receptors in rat renal cortex closely related to the thiazide-sensitivee Na/Cl transport pathway of the renal distal tubule... DH Ellison,J Morrisey,GV Desir - Biochimica...