Thiazolidines undergo hydrolysis to aldehyde andamino thiolunder acid or basic aqueous conditions. The mechanism of the reaction of some model compounds has been investigated bykinetic measurementsunder different conditions〈91JA3071〉. It has been concluded that the reaction involves CS bond breaking an...
The process involves a three-component coupling of an alkyne, an aldehyde, and an amine (A3-coupling) followed by trapping the resulting propargylamine with carbon disulfide and subsequent cyclization. 展开 DOI: 10.1002/ejoc.201601103 年份: 2017 收藏 引用 批量...
Herein, we present a new methodology to prepare 2-substituted bisthiazolidines by aldehyde exchange. Thirteen new bisthiazolidines were prepared using this methodology, with yields ranging from 31 to 75 %. The reaction is based on in situ imines formation, which are able to exchange side chains...
Corresponding aldehyde from aforementioned reaction was added to the mixture of tert-butyl 2-(2,4-dioxothiazolidin-3-yl)ethylcarbamate (260 mg, 1.0 mmol) and piperidine (25.5 mg, 0.3 mmol) in 15 mL of anhydrous ethanol. The clear solution was heated and refluxed overnight and detected with...
(such as aniline, benzophenone, or the like), carbonyl alkyl piperazine, oxyalkylene, aldehyde, amino, aniline, or the like, R2 represents a substituent other than hydrogen bonded to one of the ring carbon atoms, by either a single or double bond, such as oxo ( O) or the like, and ...
===bfoCeiRaocmBROCathnrlC2tp=R´HRediHootORB227n3e=au=1e8RrnnbnHHo2dzy˝d=co(C(ys1r5tH(eh9c%31acl%e(7–ri)n5%rcy5)0des%)rwftiaof)nolerlgeirlzleoaeactwxniaoidesrntrdaiaaenrbsdeyatowxauinost electrorepphoirlteedquinenpcahrenwtihtehsebse).nSz-Maldehyde (at R2 ´78 ˝C) (...