Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression od apolipoprotein C-III. J Biol Chem 1995;270:13470-5. 7.Galli A, Stewart M, Dorris R, et al. High-level expression of RXRalpha and the presence of endogenous ligands contribute to expression of a peroxisome ...
TZD also increased IRS-2 mRNA levels in cultured human adipose tissue. These data show the first direct link between TZD and a critical molecule in insulin's signaling cascade in both 3T3-L1 and human adipocytes, and indicate a novel mode of action of these compounds. 展开 ...
Its novel mode of action, which is also seen in other thiazolidinediones, has given rise to considerable interest in this class as a whole. Rather than increasing insulin secretion, these agents act by increasing sensitivity to insulin. As with any new class of drugs, their discovery has led ...
The effective dosage of active ingredient employed may vary depending on the particular compound employed, the mode of administration, the condition being treated and the severity of the condition being treated. Such dosage may be ascertained readily by a person skilled in the art. When treating or...
Compounds 11 and 12 also inhibited thymidylate synthase with IC50 values of 5.1 and 3.2 μM, respectively, confirming their mode of action as thymidylate synthase inhibitors. Finally, molecular docking studies supported the in vitro biological activity results...
We conclude that thiazolidinediones enhance insulin responsiveness in skeletal muscle during glucocorticoid treatment, but their mode of action in this setting is not via upregulation of GLUT4 expression.doi:10.1016/0026-0495(93)90139-FS. P. Weinstein...