Mechanism of action of thiazolidinediones. Curr Opin Invest Drugs 2001; 2 (11): 1564-7Girard J. Mechanisms of action of thiazolidinediones. Diabetes and Metabolism . 2001; 27 (2):271–278. [ PubMed ]Girard J. Mechanisms of action of thiazolidinediones . (2001) Diabetes Metab 27 : 271–8...
Most of the genes responsible for insulin signaling were unaffected. Administration of pioglitazone was also shown to induce PPARgamma expression in liver and muscle. It is therefore possible to hypothesize that TZDs may ameliorate diabetes through a mechanism of action involving a direct decrease in ...
In 2005, the US Food and Drug Administration (FDA) held an advisory committee meeting to help determine the safety of selective cyclooxygenase 2 (COX-2) inhibitors, a popular group of drugs with a novel mechanism of action but with incompletely understood effects on the cardiovascular system......
Smith U. Pioglitazone: mechanism of action. Int J Clin Pract Suppl 2001 Sep; 121: 13–8 PubMedCASGoogle Scholar Lebovitz HE. Differentiating members of the thiazolidinedione class: a focus on safety. Diabetes Metab Res Rev 2002; 18 Suppl. 2: S23–9 ArticlePubMedCASGoogle Scholar http://...
These shortcomings have provided an incentive to develop better insulin sensitizers for Type 2 diabetes which 20 function via similar mechanism(s) of action. Recently, there have been reports of compounds that are PPAR gamma antagonists or PPAR partial agonists. WOO 1/30343 describes a specific ...
Unraveling the mechanism of action of thiazolidinediones. Kahn C R,Chen L,Cohen SE. Clinical Investigator . 2000C. R. Kahn, L. Chen, and S. E. Cohen, "Unraveling the mech- anism of action of thiazolidinediones," The Journal of Clinical Investigation, vol. 106, no. 11, pp. 1305-1307...
Although the precise mechanism of action of these drugs remains unknown, transcriptional changes that produce enhanced insulin action are observed in tissue culture cells. Clinical studies are underway to evaluate the safety and effectiveness of thiazolidinediones in non-insulin-dependent diabetes mellitus ...
correction of diabetic dyslipidemia, improvement of fibrinolysis, and decrease in carotid artery intima-media thickness.In this chapter we summarize the current knowledge about Thiazolidinediones, the intracellular mechanism of action and discuss their potential role in the treatment of diabetes associated mi...
Thiazolidine-2,4-diones, a new class of oral antihyperglycemic agents, have been shown to be effective in improving insulin sensitivity in a number of animal models of insulin resistance, and recent investigation has suggested that the mechanism of action of these agents may include upregulation ...
In contrast, the TZDs demonstrate insulin-sensitizing effects attributable to their novel mechanism of action on the peroxisome proliferator-activated receptor gamma. The resulting reduction in insulin resistance appears to improve many of the metabolic and cardiovascular pathways influenced by insulin ...