2006. Therapeutic range for unfractionated heparin therapy: age-related differences in response in children. J Thromb Haemost, 4:2280-2.Ignjatovic V,Summerhayes R,Than J, et al.Therapeutic range for unfractionated heparin therapy: agerelated differences in response in children. Journal of Thrombosis...
The American College of Chest Physicians (ACCP) recommends that the activated partial thromboplastin time (aPTT) therapeutic range for unfractionated heparin be defined as the aPTT corresponding to a heparin concentration of 0.3-0.7 micro/mL by heparin anti-factor Xa assay. This recommendation suggests...
The UFH therapeutic range was determined using 3 previously described methods: calibration of the aPTT to 0.3 to 0.7 U/mL anti-Xa activity, application of 1.5 to 2.5 times the control aPTT, or using 0.3 to 0.7 U/mL anti-Xa activity directly. We also applied the UFH therapeutic range of ...
The results of molecular function showed that DEGs were mainly enriched in calcium ion binding, heparin binding, growth factor activity and steroid hormone receptor activity (Fig. 2F, Supplementary Table S2). KEGG pathway analysis of DEGs showed that the top four significant pathways were enriched ...
Heparin or heparan sulphate glycosaminoglycans (HSGAGs). Long chains of repeated saccharide units that can be variably sulphated or acetylated, allowing for considerable structural diversity. HSGAGs are located in the extracellular matrix of the surface of every cell, where they modulate the activity ...
An UpToDate review on “Management of heparin-induced thrombocytopenia” (Coutre and Crowther, 2020) states that “Other approaches, including fibrinogen-depleting agents (e.g., ancrod), thrombolysis, plasmapheresis, or dextran, are either not effective or are unproven for the routine initial treatme...
Latter studies were approved by the ethics committee of the University of Lübeck (09–140). 2.2. Cytokines in peripheral blood cells 1 × 106 cells from heparin-NH4-treated patient/control blood were suspended in 100 μl RPMI 1640 medium and stimulated with 250 ng/ml phorbol ...
and heparin binding EGF-like growth factor and the group of low-affinity ligands including EREG, epigen (EPGN) and amphiregulin (AREG) [19]. Although former studies reported distinct EGFR-dependent cellular responses to various ligands [41], the paracrine influence of stromal EREG on global expre...
et al. A novel function of angiotensin II in skin wound healing. Induction of fibroblast and keratinocyte migration by angiotensin II via heparin-binding epidermal growth factor (EGF)-like growth factor-mediated EGF receptor transactivation. J. Biol. Chem. 281, 13209–13216 (2006). Article CAS ...
The distal end of the catheter was exteriorized at the nape of the neck, filled with heparin (1000 units/ml) and heat sealed. For bladder catheterization, the bladder was exposed through a midline abdominal incision. A trocar was passed through the abdominal muscle about 1 cm from the upper...