however, the high ptt result, which was at the upper end of the therapeutic range for ufh at our institution (75-108 seconds, corresponding to anti-xa levels of 0.3-0.7 u/ml), was alarming during this life-threatening bleeding episode, caused confusion about the validity of the result, ...
The therapeutic range while on heparin therapy would be 45-75 seconds (or 1.5 – 2.5 times the mean normal value). When an IV bolus of heparin is given, followed by a continuous IV infusion, the aPTT is evaluated every 6 hours during the first day of heparin therapy & 6 hours after ...
•Derivedfrombovinelungor porcinegut •~12000Da •EquipotentagainstFIIaand Xa •Intravenousor subcutaneousadministration LowMolecularWeightHeparinUnfractionatedHeparin •Doesnotusuallyrequire therapeuticmonitoring (responseisdose-dependent) •~10Xmoreexpensive •Lowerriskofimmune sensitizationandHIT ...
Therapeutic value: 60-80 seconds, an increase in the aPTT by a factor of 1.5 to 2. Therapeutic Uses acute MI, PE, evolving stroke and massive DVT and can olso be used for (low dose) prevention post-op venous thrombosis. Adverse Effect HEMORRHAGESigns and Symptoms: bleeding in the mucous...
3. 4. GreinacherA,EichlerP,LubenowN,KwasnyH,LuzM:Heparin-induced thrombocytopeniawiththromboemboliccomplications:meta-analysisof 2prospectivetrialstoassessthevalueofparenteraltreatmentwith lepirudinanditstherapeuticaPTTrange.Blood2000,96:846-851. GreinacherA,VolpelH,JanssensU,Hach-WunderleV,Kemkes-MatthesB,...
Results: Time to first exceed therapeutic threshold was 16.5卤16.3 hours (hrs) and time to goal therapeutic range was 25卤24.3 hrs. At 6 hours, 58% had not surpassed the therapeutic threshold; 46% were subtherapeutic at 24 hrs. Major bleeding occurred in 6 (12%) patients (PTT range 35...
PTT values were extracted from patient profiles for the duration of UFH infusion. These values were used to find the duration of time in target PTT range (70-90.9 sec); subtherapeutic (PTT<70 sec); and supratherapeutic (PTT>90.9 sec) epochs. Duration of time above theraputic PTT and mean...
Patients were divided into pre-protocolnd post-protocol groups.esults: Primaryutcome waso evaluatehe numberfherapeutic,ubtherapeutic,ndupratherapeuticPTTsetweenwo groups. Inhe pre-protocol group,PTTs wereherapeutic,ubtherapeutic,ndupratherapeutic 48.5% (164/338), 14.2% (48/338),nd 37.2% (126/...
A modified UFH dosing approach should be applied during TH to avoid supra-therapeutic heparin dosing. We recommend a 40 Unit per kilogram bolus dose and a 7 Unit/kg/hour starting rate during TH, with further adjustments based on aPTT. This reduced dosing protocol may reduce the incidence of ...
therapeutic plasma exchange; U-cpb, UFH given during cardiopulmonary bypass (heart) surgery; U-hd, heparin for hemodialysis; U-MI, heparin for myocar- dial infarction; U-Pr, prophylactic-dose heparin; U-rx, therapeutic-dose (treatment-dose) heparin; vasc, vasular surgery; VLG, venous limb ...