therapeutic rangeanti‐Xa activityIntroduction Unfractionated heparin (UFH) therapy is monitored by using the anti‐activated factor X (anti‐Xa) activity, or the activated partial thromboplastin time (APTT), which remains the most widely used assay. One of the main advantages of anti‐Xa relies ...
The American College of Chest Physicians (ACCP) recommends that the activated partial thromboplastin time (aPTT) therapeutic range for unfractionated heparin be defined as the aPTT corresponding to a heparin concentration of 0.3-0.7 micro/mL by heparin anti-factor Xa assay. This recommendation suggests...
BACKGROUND: Protocolled treatment with unfractionated heparin (UFH) is a subject of ongoing debate. Even though international guidelines prescribe calibration of the activated partial thromboplastin time (aPTT) to 0.3 to 0.7 U/mL anti-Xa activity to establish an UFH therapeutic range, evidence for ...
241 RISK OF SUPRATHERAPEUTIC APTT IN THE ABSENCE OF AN INITIAL UNFRACTIONATED HEPARIN BOLUS F Bonenfant, B Cossette, V Nault, M Turgeon, M Paulin, D Echenberg, P Charron, M Lépine, T Fayad, P Farand Sherbrooke, Québec BACKGROUND: Unfractionated heparin (UFH) is an anticoag- ulant ...
(APTT).7About 60% ICU patients had abnormally elevated D-dimer levels compared with a prevalence of 43% in non-severe patients.131Moreover, increased D-dimer levels were associated with adverse prognosis.132In severe COVID-19 patients, thrombotic complications are common due to the prothrombotic...
[116]. In addition, LMWH has been associated with lower rates of heparin-induced thrombocytopenia and traumatic hematoma expansion [117,118]. On the other hand, UFH has a shorter half-life and is more easily reversed. Therefore, UFH may be the preferred agent in high-risk situations with ...
therapeutic rangeactivated partial thromboplastin timeAPTTanti-FXa assayIntroduction: Heparin is one of the oldest biological medicines with an established role in prevention and treatment of arterial and venous thromboembolism. Published therapeutic ranges for unfractionated heparin (UFH) mostly precede the ...
The recommendation was to adjust the dose of unfractionated heparin in order to prolong the activated partial thromboplastin time (aPTT) to a range that corresponds to a heparin level of 0.2 to 0.4 U/mL by protamine titration or 0.3 to 0.6 or 0.7 U/mL by heparin anti-factor Xa analysis....
of heparin therapy from the patients' medical records.Descriptive analysis of the data revealed 32% of the participants attained a therapeutic level with the first aPTT taken and that, successively, 35% and 45% of the participants attained a therapeutic level with the second and third aPTT taken...
APTT therapeutic range for monitoring unfractionated heparin therapy. Significant impact of the anti-Xa reagent used for correlation: COMMENTdoi:10.1111/jth.15356Michael J. KovacsDepartment of Medicine Western University London ON CanadaAlejandro Lazo-Langner...