One of the main advantages of anti‐Xa relies on its hypothesized standardization, with a unique therapeutic range (0.30‐0.70 IU/ml) for all reagents, whereas APTT is influenced by numerous preanalytical and analytical parameters not related to the anticoagulant activity of UFH. Methods The aim ...
The American College of Chest Physicians (ACCP) recommends that the activated partial thromboplastin time (aPTT) therapeutic range for unfractionated heparin be defined as the aPTT corresponding to a heparin concentration of 0.3-0.7 micro/mL by heparin anti-factor Xa assay. This recommendation suggests...
S. et al. Antisense inhibition of coagulation factor XI prolongs APTT without increased bleeding risk in cynomolgus monkeys. Blood 119, 2401–2408 (2012). CAS PubMed Google Scholar Buller, H. R. et al. Factor XI antisense oligonucleotide for prevention of venous thrombosis. N. Engl. J. ...
241 RISK OF SUPRATHERAPEUTIC APTT IN THE ABSENCE OF AN INITIAL UNFRACTIONATED HEPARIN BOLUS F Bonenfant, B Cossette, V Nault, M Turgeon, M Paulin, D Echenberg, P Charron, M Lépine, T Fayad, P Farand Sherbrooke, Québec BACKGROUND: Unfractionated heparin (UFH) is an anticoag- ulant ...
BACKGROUND: Protocolled treatment with unfractionated heparin (UFH) is a subject of ongoing debate. Even though international guidelines prescribe calibration of the activated partial thromboplastin time (aPTT) to 0.3 to 0.7 U/mL anti-Xa activity to establish an UFH therapeutic range, evidence for ...
(APTT).7About 60% ICU patients had abnormally elevated D-dimer levels compared with a prevalence of 43% in non-severe patients.131Moreover, increased D-dimer levels were associated with adverse prognosis.132In severe COVID-19 patients, thrombotic complications are common due to the prothrombotic...
Standard coagulation tests (PT, aPTT) are not suitable for detecting a NOAC effect but, depending on the NOAC, they may indicate the presence of an anticoagulant. The effects of anticoagulant therapy on these tests vary according to the dose and the time elapsing since ingestion. However, meani...
of heparin therapy from the patients' medical records.Descriptive analysis of the data revealed 32% of the participants attained a therapeutic level with the first aPTT taken and that, successively, 35% and 45% of the participants attained a therapeutic level with the second and third aPTT taken...
APTTanti-FXa assayIntroduction: Heparin is one of the oldest biological medicines with an established role in prevention and treatment of arterial and venous thromboembolism. Published therapeutic ranges for unfractionated heparin (UFH) mostly precede the large increase in the number of activated partial...
APTT therapeutic range for monitoring unfractionated heparin therapy. Significant impact of the anti-Xa reagent used for correlation: COMMENTdoi:10.1111/jth.15356Michael J. KovacsDepartment of Medicine Western University London ON CanadaAlejandro Lazo-Langner...