Objective To evaluate the therapeutic effect of low molecular weight heparin (LMWH) combined with ulinastatin (UTI) on acute pancreatitis (AP). Methods One hundred age, and sex-matched AP patients were randomly divided into four equal groups: Group A (control group), Group B undergoing subcutaneo...
Moreover, these properties were confirmed at a higher technological level during the COVID-19 pandemic.doi:10.1007/s10517-024-06120-0Kondashevskaya, M. V.Artemyeva, K. A.Aleksankina, V. V.Mikhaleva, L. M.Springer USBulletin of Experimental Biology & Medicine...
(P0.05,P0.01).HE dyeing patho-observation showed bleeding and pulmonary fibrosis were relieved in group C compared with those in group B(P0.05).Conclusion Low molecular weight heparin may reduce the synthesis of matrix metalloproteinase-9 and relieve fibrosis degree by influencing the level of ...
the central nervous system (CNS) is protected by the blood brain barrier (BBB)14. This anatomical and functional barrier impedes the trafficking of immune cells originating in the systemic
At the molecular level, ALDH2 increased K48-linked polyubiquitination and degradation of peptidylarginine deiminase 4 (PAD4) to inhibit NETosis, which was achieved by promoting PAD4 binding to the E3 ubiquitin ligase CHIP. Pharmacological administration of the ALDH2-specific activator Alda-1 ...
Furthermore, biopharmaceuticals must be of high quality to assure safety and effectiveness in target applications. We had previously reported that recombinant human prethrombin-2 expression level in a stable cell line established using the mouse myeloma cells, Sp2/0-Ag14, reached 200μg/mL using ...
et al. Increased circulatory level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia. J. Clin. Endocrinol. Metab. 87, 4957–4960 (2002). CAS PubMed Google Scholar Imel, E. A., Hui, S. L. & Econs, M. J. FGF23 concentrations vary with ...
This randomized clinical trial evaluates the effects of therapeutic-dose low-molecular-weight heparin vs standard prophylactic or intermediate-dose
Coma represents a severely depressed level of responsiveness that is typically diagnosed with the Glasgow Coma Score (GCS, score < 8 representing coma) or the Full Outline of UnResponsivenss (FOUR) score [72, 73]. The Richmond Agitation-Sedation Scale (RASS) has also been used to ...
PP2A activity is significantly decreased in the AD cortex and hippocampus [145,147,150]. The level of tau hyperphosphorylation at many sites is negatively correlated with PP2A activity [151]. Up-regulation of I1PP2Aand I2PP2A, and mislocalization and cleavage of I2PP2Acould underlie the inactiv...