Proteins are considered magic molecules due to their enormous applications in the health sector. Over the past few decades, therapeutic proteins have emerged as a promising treatment option for various diseases, particularly cancer, cardiovascular disease, diabetes, and others. The formulation of protein...
The new found hope in mitochondrial PPI targeting is the group of peptides, namely, mitochondria-penetrating peptides (MPPs). The MPPs are basically a sub-class of cell penetrating peptides (CPP) constructed with a short peptide sequence of 3–10 amino acids e.g., (rFrFrF, SS-01, and...
Therapeutic plasma exchange (TPE) is a routine method that separates plasma from blood cells to remove pathological factors or to deliver deficient ones. Consistently, it is used for numerous diseases characterized by the presence of harmful circulating factors or the deficiency of protective components...
the physiologically coagulation-inducing effects of which have long been exploited. Other compounds belonging to this class of substances (e.g. heparins and heparinoids) are used to treat hyperlipemias and hypercholesteremias, or as antiarthrotic agents (e.g. extracts of cartilage and chondroitin...
The differentiating daughter cells move through the epithelium, acquiring specialised properties until they are released from the source as part of tissue renewal.Citation24 HPV infection is initiated with the binding of the major capsid protein, L1 to heparin sulfate proteoglycan (HSPGs) or laminin ...
The results of molecular function showed that DEGs were mainly enriched in calcium ion binding, heparin binding, growth factor activity and steroid hormone receptor activity (Fig. 2F, Supplementary Table S2). KEGG pathway analysis of DEGs showed that the top four significant pathways were enriched ...
17. Product according to claim 16 wherein said liquid contains a mineral salt, a local anesthetic, one or more vitamins and heparin. Description: The present invention relates to a therapeutic product formed by the association of an organic derivative of silicon with a polyamine carrying hydrocarbo...
An UpToDate review on “Management of heparin-induced thrombocytopenia” (Coutre and Crowther, 2020) states that “Other approaches, including fibrinogen-depleting agents (e.g., ancrod), thrombolysis, plasmapheresis, or dextran, are either not effective or are unproven for the routine initial treatme...
domains play a crucial role in binding to various proteins; A1 interacts with high molecular weight kininogen (HK) and thrombin [2], A2 and A3 bind to FIX [3], A3 interacts with the platelet receptor GP1bα and heparin [4], and A4 binds to FXII and the other subunit of FXI [5, ...
Heparin and tranexamic acid therapy may be effective in treatment-resistant chronic urticaria with elevated D-dimer: a pilot study. Int Arch Allergy Immunol. 2010;152(4):384–9. 151. Folci M, Heffler E, Canonica GW, Furlan R, Brunetta E. Cutting edge: biomarkers for chronic spontaneous ...