The mean serum digoxin concentration six hours after the morning oral dose of digoxin in 28 of the 41 patients, with normal serum creatinine values, was 1.3 ng/ml (S.D. 0.4 ng/ml), and in the other 13 patients with mildly elevated serum creatinine values (range 1.3 to 1.6 mg/dl for...
Objective To discuss the importance of blood concentration monitoring in more individualized and rationalized administration of Digoxin. 目的:探讨血药浓度监测对个体化、合理化用药的重要作用。 更多例句>> 5) blood drug level monitoring 血药浓度监测 1. METHODS:With the aid of windows 98 operating pla...
measuring the plasma level of aripiprazole and its active metabolite dehydroaripiprazole after a week of treatment, while another performed on Asian patients from Taiwan reported a higher clinical response with aripiprazole serum concentrations higher than the TRR proposed for the western population [19,...
Digoxin 0.8-2 ng/mL Gentamicin (Garamycin) 5-10 mcg/mL Lidocaine 1.5-5.0 mcg/mL Lithium 0.4-1.4 mEq/L Magnesium Sulfate 4-8 mg/dL Phenobarbital 10-40 mcg/mL Phenytoin (Dilantin) 10-20 mcg/mL Salicylate 100-250 mcg/mL Theophylline 10-20 mcg/mL Tobramycin 5-10 mcg/mL trough drug le...
Recent advancements in gene therapy have opened an avenue for the possible prevention of IDD development at the transcriptional or post-transcriptional levels8,9,10,11. There is therefore the need for a more in-depth understanding of IDD to facilitate the development of new therapeutic strategies12...
For digoxin, a substantial interindividual variation in the S/P ratio has been found in patients on long-term therapy, which makes the use of saliva for digoxin monitoring doubtful. Due to the substantial inter- and intraindividual variation in the S/P ratio of procainamide in patients on long...
In the DIG trial, cardiac glycosides were able to decrease the risk for overall hospitalization and hospitalization due to worsening HF in patients with HFrEF and HFpEF (LVEF > 45%) [58]. On the contrary, there have been no significant differences between digoxin and placebo regarding overa...
et al. Population-level analysis of gut microbiome variation. Science 352, 560–564 (2016). Article ADS CAS PubMed Google Scholar Maier, L. & Typas, A. Systematically investigating the impact of medication on the gut microbiome. Curr. Opin. Microbiol. 39, 128–135 (2017). Article CAS ...
Level of evidence: 1. Level of agreement: 91%Randomised controlled studies with oral budesonide MMX have shown it to be more effective than placebo, and to be as effective as oral 5-ASAs for inducing remission. However, this has not been demonstrated with other formulations of ileal-release ...
[126], this may not be the case for some TmAbs, including rituximab, as the expression level of CD20 on B cell-chronic lymphocytic leukemia (B-CLL) cells does not affect the efficacy of the antibody’s mediated ADCP [126]. This mechanism involves the participation of FcγRIIa (CD32a)...