The mean serum digoxin concentration six hours after the morning oral dose of digoxin in 28 of the 41 patients, with normal serum creatinine values, was 1.3 ng/ml (S.D. 0.4 ng/ml), and in the other 13 patients with mildly elevated serum creatinine values (range 1.3 to 1.6 mg/dl for...
Objective To discuss the importance of blood concentration monitoring in more individualized and rationalized administration of Digoxin. 目的:探讨血药浓度监测对个体化、合理化用药的重要作用。 更多例句>> 5) blood drug level monitoring 血药浓度监测 1. METHODS:With the aid of windows 98 operating pla...
The major support for using digoxin at present is in atrial fibrillation (AF) with a rapid ventricular response (Whayne, 2018). Due to the very narrow therapeutic window of the medication (Pashazadeh-Panahi and Hasanzadeh, 2020), it is needed to maintain the serum digoxin level at ≤1.0 ng...
Type 2 diabetes (T2D) and Clear-cell renal cell carcinoma (ccRCC) are both complicated diseases which incidence rates gradually increasing. Population based studies show that severity of ccRCC might be associated with T2D. However, so far, no researcher
in some patients, the production of human anti-mouse antibodies (HAMA); these are endogenous antibodies with specificity for antigenic determinants present in the Fc region of mouse Igs [19]. Production of HAMA accelerates mAb clearance, thus reducing its serum half-time; on the other hand, rep...
Administration of quercetin for several months at a concentration above 1000 mg/day did not show side effects on serum electrolytes, blood parameters of renal and hepatic functions or hematology. Hence, no evidence of toxicity was found, however long-term safety data at high doses of quercetin ...
Most antiarrhythmic drugs fulfil the formal requirements for rational use of therapeutic drug monitoring, as they show highly variable plasma concentration
Human NP tissues were sliced into 1-mm3 pieces and washed twice with 10% fetal bovine serum (PBS) (Gibco, NY, USA), followed by incubation in DMEM (Gibco, NY, USA). Subsequently, a resuspension of NP cells was cultured in DMEM, 1% penicillin–streptomycin, and 10% FBS. The cells wer...
For digoxin, a substantial interindividual variation in the S/P ratio has been found in patients on long-term therapy, which makes the use of saliva for digoxin monitoring doubtful. Due to the substantial inter- and intraindividual variation in the S/P ratio of procainamide in patients on long...
1B). In addition, the level of IL-35 in serum was positively and significantly correlated with IL-6, IL-10 and the oxygenation index (PaO2/FiO2 ratio) but negatively correlated with TNF-α, IL-1β and APACHE II score during ARDS (Fig. 1C and D). Furthermore, the proportion of ...