In recent years, digoxin use has been on the decline, with decreased incidence of digoxin toxicity. Hence, digoxin toxicity, when it occurs, remains an elusive diagnosis to emergency physicians. To present a case of digoxin toxicity with normal levels of digoxin and serum potassium, but with ...
Digoxin bioavailability was studied in 6 normal volunteers during chronic dosing. The absorption of digoxin was estimated by: (1) steady-state serum dtgoxin levels; (2) the area IInder the serllm concentration-time curve (AUC) du ring a dosittg interval; and (3) the excretion of digoxin ...
Digoxin 0.8 mg/dL 2.0 mg/dL ≥ 2.1 mg/dL Gentamicin Trough: 1.0 mcg/mL Peak: 5.0 mcg/mL Trough: 1.9 mcg/mL Peak: 8.0 mcg/mL Trough: ≥ 2.0 mcg/mL Peak: ≥ 12.0 mcg/mL Random: ≥ 2.0 mcg/mL Phenobarbital 10.0 mcg/mL 30.0 mcg/mL ≥ 50.0 mcg/mL Phenytoin 10.0 mcg/...
In both trials, digoxin had no effect on the mortality of chronic HF patients in normal sinus rhythm but reduced their need for worsening HF hospitalizations. Specific clinical characteristics of the patients recruited for the ancillary trial have been reported (32), and again suggested a high ...
Joubert DH, Muller FO, Pansegrouw PF, Kleynhans PHT (1975) A correlative study of serum digoxin levels and electrocardiographic measurements. S Afr Med 49: 1177–1181 About this Article Title The comparative cardiovascular effects of digoxin and food alone and in combination in normal males Jou...
When rats suffering from protein-calorie malnutrition (kwashiorkor) were given chloroquine, urinary levels of unchanged drug increased while chloroquine me... SA Adelusi - 《Experientia》 被引量: 6发表: 1982年 Digoxin binding to proteins in kwashiorkor and normal serum The binding of chloroquine to...
detected, besides P-gp, high levels of Mrp1 in lungs of mice [4]. Mrp1 (-/-) mice develop normally [67]. Viability, fertility, and a range of histological, hematological, and serum-chemical parameters were similar in Mrp (+/+) and Mrp (-/-) mice. However, Mrp1 (-/-) mice ...
Serum digoxin-immunoreactive substance levels did not demonstrate good correlation with gestational age and systolic blood pressure in preeclamptic pregnancies.An endogenous digoxin-immunoreactive substance is present in the sera of third trimester pregnant women, but it does not contribute to the ...
Phosphate-buffered saline (PBS) containing 1% bovine serum albumin (BSA) was used as diluent and wash solution. Primary antibody incubations were for one hour in a humidified chamber; secondary antibody, if needed, was applied for 30 minutes. Sections were mounted in Vectashield containing DAPI ...
Kaufmann B, Olcay A, Schaumann W, Teufel W, Weih W., (1981) Pharmacokinetics of metildigoxin and digoxin in geriatric patients with normal and elevated serum creatinine levels. Clin Pharmacokinet 6: 463Kaufmann, B., Olcay, A., Schaumann, W. et al.: Pharmacokinetics of metildigoxin and ...