Three counter-balanced infusions separated by 48 h were received: lorazepam (2 mg) and two doses of ketamine (0.41 mg/kg and 0.71 mg/kg, with the former dose always preceding the latter). Infusions were followed within 15 min by measures of dissociation (Clinician Administered...
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly t
Ludtke KA, Stanley KS, Yount NL, Gerkin RD. Retrospective review of critically ill patients experiencing alcohol withdrawal: dexmedetomidine versus propofol and/or lorazepam continuous infusions. Hosp Pharm. 2015;50(3):208–13. ArticleCASPubMedPubMed CentralGoogle Scholar Mohorn PL, Vakkalanka JP,...
The Effects of Carbamazepine and Lorazepam on Single versus Multiple Previous Alcohol Withdrawals in an Outpatient Randomized Trial OBJECTIVE: Benzodiazepines are the mainstay of treatment for mild-to-moderate alcohol withdrawal in outpatient settings, but they can interact with alcohol... R Malcolm,H ...
Self-reported sleep, sleepiness, and repeated alcohol withdrawals: a randomized, double blind, controlled comparison of lorazepam vs gabapentin. J Clin Sleep Med 3: 24–32. Mariani JJ, Rosenthal RN, Tross S, Singh P, Anand OP (2006). A randomized, open- label, controlled trial of ...
et al. Efficacy of etifoxine compared to lorazepam monotherapy in the treatment of patients with adjustment disorders with anxiety: a double-blind controlled study in general practice. Human Psychopharmacology 21, 139–149 (2006). Article CAS PubMed Google Scholar Langer, S. Z., Arbilla, S.,...
selectivity of clobazam compared with PF-06372865, as its metabolite N-desmethyl clobazam has greater selectivity for α2 GABAA receptors over α1 GABAA receptors compared with the parent.48 Similar to our findings, CPM was not affected by treatment with the non-selective benzodiazepine lorazepam.49...
5. Product according to claim 3, the psychotropic drug is a GABAergic effector chosen from tiagabine, topiramate, clorazepate, diazepam, clonazepam, oxazepam, lorazepam, bromazepam, lormetazepam, nitrazepam, clotiazepam, alprozolam, estazolam, triazolam, loprazolam, etifoxin, meprobamate, ...
carbamazepine and barbiturates. Valproate itself is devoid of enzyme-inducing properties, but it has the potential of inhibiting drug metabolism and can increase by this mechanism the plasma concentrations of certain coadministered drugs, including phenobarbital (phenobarbitone), lamotrigine and zidovudine....
Due to the complex and diverse nature of epilepsy and antiepileptic drugs (AEDs), the implementation of therapeutic drug monitoring (TDM) can contribute significantly to the overall improvement of clinical outcome in epilepsy. Establishing and interpreting an individual serum drug concentration range by ...