and fluvoxamine have significant drug-drug interactions and are therefore less commonly used in older adults [36]. SSRIs are also associated with risks of hyponatremia and gastrointestinal bleeding, especially in patients on Cholinesterase Inhibitors (CHEIs) or anticoagulants [7]. Also, they are asso...
Influence of Certain Calcium‐channel Blockers on Some Aspects of Lorazepam‐dependence in Mice The effect of acute and chronic treatments of the calcium-channel blockers, isradipine, diltiazem and flunarizine in protecting against lorazepam dependenc... SF Saad,MT Khayyal,AS Attia,... - 《Journa...
Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly t
Overall, 12 670 participants were randomly assigned to placebo and 35 280 to one of the following medications: benzodiazepines (short half-life: alprazolam, brotizolam, midazolam, and triazolam; intermediate half-life: estazolam, loprazolam, lorazepam, lormetazepam, and temazepam; long half-...
The long duration of salmeterol has also been suggested to depend on an anchored binding within the β 2-receptor (I). The pharmacological evidence for a rapid onset of action of formoterol, but long duration of effect, is supported by several clinical studies. The fast onset of broncho...
Such drugs are largely devoid of active metabolites which can prolong the duration of many of the older benzodiazepines, e.g. flurazepam.The short and intermediate half-life benzodiazepines have elimination half-lives of 5-24 hours. Drugs of this type, which include lorazepam, alprazolam, ...
lorazepamFG7142ethopharmacologyanimalmodelsUsing a within-subject cross-over, vehicle-controlled design, we investigated the acute effects of benzodiazepine receptor ligands with different mechanisms of action on the displacement activities (scratching, self-grooming, and body shake) of seven male macaques ...
lorazepamFG 7142ethopharmacologyanimal modelsUsing a within-subject cross-over, vehicle-controlled design, we investigated the acute effects of benzodiazepine receptor ligands with different mechanisms of action on the displacement activities (scratching, self-grooming, and body shake) of seven male ...
Recent advances have been made in understanding the neurobiology of fear and anxiety, and elucidating the nature of the neurotransmitters involved in these processes. These findings are, at last, improving the prospect of alternatives to the benzodiazepines in the treatment of anxiety disorders. ...
Benzodiazepines and/or antipsychotic medications are often used and can be given intramuscularly to achieve a rapid onset of action. Available are intramuscular preparations of second-generation antipsychotics that have similar efficacy to lorazepam and haloperidol in reducing agitation, but are well ...