A 16-year-old female confessed to having intentionally ingested 20–25, 225 mg extended-release capsules of propafenone (4.5–5.6 g) in a suicide attempt. She developed sudden generalized tonic-clonic seizure and markedly prolonged QRS duration with a Brugada-like pattern on ECG. Lorazepam, ...
Aggressive supportive care is the mainstay of treatment provided to patients in the intensive care unit (ICU). Basic aspects of care must be reevaluated or adjusted to account for unique aspects in the pathophysiology of the critically ill poisoned patient. This may include the use of gastrointes...
Here, we will present some examples of medications that work on the GABA system and represent promising thera- pies for the treatment of alcohol and drugs use disorders, ie, baclofen, gabapentin, and topiramate. It should also be noted that these medications are not direct dopaminergic drugs ...
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We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
In this study, 153 dependent patients using 14 different benzodiazepines were evaluated to assess the prevalence of their use among high vs. therapeutic dose dependants. Triazolam was the single drug most frequently used by high-dose dependants, followed by Lorazepam. No significant differences were ...
Compounds devoid of α1GABAAR-mediated sedation should circumvent this problem. However, none of the currently available compounds with improved α2GABAAR selectivity have so far been approved for use in humans. We therefore evaluated alternative possibilities for proof-of-concept studies in humans. ...
The Effects of Carbamazepine and Lorazepam on Single versus Multiple Previous Alcohol Withdrawals in an Outpatient Randomized Trial OBJECTIVE: Benzodiazepines are the mainstay of treatment for mild-to-moderate alcohol withdrawal in outpatient settings, but they can interact with alcohol... R Malcolm,H ...
Thirty-five years since its introduction into clinical use, valproate (valproic acid) has become the most widely prescribed antiepileptic drug (AED) worldwide. Its pharmacological effects involve a variety of mechanisms, including increased γ-aminobutyric acid (GABA)-ergic transmission, reduced release...
(oxcarbazepine) OR TS = (fluvoxamine) OR TS = (fluoxetine) OR TS = (sertraline) OR TS = (paroxetine) OR TS = (citalopram) OR TS = (escitalopram) OR TS = (venlafaxine) OR TS = (duloxetine) OR TS = (bupropion) OR TS = (trazodone) OR TS = (lorazepam) OR TS = (alprazolam))....