Theory of protein foldingJose ´ Nelson Onuchic1,2,?and Peter G Wolynes1,2,3Protein folding should be complex. Proteins organizethemselves into specific three-dimensional structures, througha myriad of conformational changes. The classical view ofprotein folding describes this process as a nearly se...
It really should be called the thermodynamic principle of protein folding. Energy landscape is really just the mathematical graph of the Gibbs free energy function G(X;U ,EN), a very high dimensional hyper surface. Without knowing it any picture of the Gibbs free energy landscape has no ...
Self-organization and mismatch tolerance in protein folding: General theory and an application The analysis of this process presented here uses a coarse, discretized representation of the evolving form of the backbone chain, based on its torsional ... A Fernández,RS Berry - 《Journal of Chemical...
The topology of folding is widely believed to define its properties and function, and knot theory has been applied to study protein structure and its implications. More that 97% of proteins are, however, classified as unknots when intra-chain interactions are ignored. This raises the question ...
Adams CC (1994) The knot book: an elementary introduction to the mathematical theory of knots. W.H. Freeman, New York MATH Google Scholar Andersson FI, Pina DG, Mallam AL, Blaser G, Jackson SE (2009) Untangling the folding mechanism of the 52-knotted protein UCH-L3. FEBS J 276(9)...
Protein folding: bringing theory and experiment closer togetherProtein folding: bringing theory and experiment closer togetherdoi:10.1016/S0959-440X(03)00007-1The ability to perform enzymatic function by harnessing random molecular motion into self-organized protein structures is one of the most fascinati...
Water molecules and molecular chaperones efficiently help the protein folding process. Here we describe their action in the context of the energy and topological networks of proteins. In energy terms water and chaperones were suggested to decrease the activation energy between various local energy minima...
Article: Water and molecular chaperones act as weak links of protein folding networks: energy landscape and punctuated equilibrium changes point to
Water molecules and molecular chaperones efficiently help the protein folding process. Here we describe their action in the context of the energy and topological networks of proteins. In energy terms water and chaperones were suggested to decrease the activation energy between various local energy minima...
Energy landscape Game theory Protein folding Punctuated equilibrium Water 1. Introduction: Water and chaperones in protein folding The start of protein folding is usually a mixture of two possible scenarios: the initial formation of major elements of the secondary structure and a fast collapse of the...