Coded language of protein folding lies in its sequence. One needs to decode this language to get the proper information about the protein structure and function. To study protein folding one needs to know various hierarchical structures, such as primary, secondary, tertiary and quaternary structures...
Chapter 3 of the book "Travels to the Nanoworld," by Michael Gross is presented. It notes how cells produce biologically active protein molecules in terms of technological approaches. It states that folding of proteins is one of the basic principles of biological molecule production of cells and...
Written by one of the leaders in this field, Introduction to Protein Architecture explains the general characteristics of proteins that underlie the very great variety of folding patterns observed in nature. For specialists in structural biology, it contains the core of what they need to know. For...
Finally, like small molecule drugs, the protein therapeutic must be formulated to produce a stable drug. Taking biopharmaceuticals from discovery to development Recombinant protein drug development starts with the identification of disease pathways that can be used to identify lead candidates. Recombinant ...
The field of folding and design of biomolecules is one of the most truly interdisciplinary areas of science. The remarkable developments in computing, electronics, X-ray crystallography and NMR, molecular and cell biology, and nucleic acid and protein chemistry have allowed us first to study structu...
Misfolding of amyloidogenic proteins is a key element of neurodegeneration. The two key requirements for nucleation to occur and the chain reaction of misfolding to spread across the brain are the presence of an initial copy of a misfolded protein and a high local concentration of a “normal”...
through genetic engineering technology, and then couple the sulfhydryl group on the cysteine to the drug molecule to synthesize a site-specific antibody-drug conjugate. This method will neither interfere with the folding and assembly of immunoglobulins nor change the binding mode of antibodies and ...
Microscopic theory of protein folding rates. II. Local reaction coordinates and chain dynamics The motions involved in barrier crossing for protein folding are investigated in terms of the chain dynamics of the polymer backbone, completing the micros... JJ Portman,S Takada,PG Wolynes - 《Journal ...
To address the need for early diagnosis of breast cancer patients,we have developed two sensitive and specific immunoassays to qualify protein Y activity and protein Y concentrations in both urine and plasma. 前言部分的写作可以采用先搭架子,再添加材料的模式。架子有三部分组成,第一部分描述课题背景,第...
Here, the most prominent example is protein folding, but also studies of protein aggregation and adsorption to soft or hard interfaces are of great medical and technological interest. While the physics concepts underlying the behavior of spin and structural glasses are still quite close, the basic ...