Study of domain organization and local folding can provide valuable information about the overall structure and function of a protein. Both theoretical and empirical approaches are developed to understand this long standing problem of science. Several theories have been used to explain the folding of ...
Protein folding is a spontaneous process. However, under physiological conditions, proteins are inherently unstable, and the protein concentrations in living cells favor unspecific interactions between partially folded proteins. Thus, the cellular proteome requires the assistance of helper factors, the molecu...
blocks; The relationship between amino acid sequence and protein structure; Secondary, supersecondary and tertiary structure; Classifications and hierarchies of protein folding patterns; Protein evolution; How proteins change conformation (and why). To suit the needs of courses, each chapter includes reco...
AP65, and α-actinin proteins that are essential forT. vaginalisfunction. A recombinantT. vaginalisprotein vaccine candidate was proposed. Computational methods were used to evaluate the interaction of the recombinant protein with TLR2 and TLR4 to assess the biological activity...
This decline may be attributed to cytotoxic effects at higher IPTG levels, inhibiting cell growth, or excessive protein synthesis rates, leading to misfolding or inclusion body formation, thereby reducing catalytic efficiency. Based on our findings, 0.4 mM IPTG was chosen as the optimal concentration...
changes from hydrophilic to hydrophobic may either destabilize the protein monomer,35 disrupt electrostatically driven protein-protein interactions40 or lead to aggregation.1,41 A first step to address this problem is to study accessibility changes at the mutation site, when going from tertiary to ...
Acetylcholine mediates its central effects through activation of two main groups of receptors, the ionotropic fast-acting nicotinic receptors and the metabotropic G protein-coupled muscarinic cholinergic receptors (mAChRs) that comprise five subtypes, namely M1–M5. M1, M3, and M5 couple to Gq and ...
An introduction to the theory of computation Anintroductiontothetheoryofcomputation theoryofcomputation 1-1 教材及主要参考书 Textbook:—MichaelSipser.IntroductiontotheTheoryofComputation(2ndEd.,InternationalEd.).北京：机械工业出版社，2006.1.(影印版).References:1.Hopcroft,J.E.,andUllman,J.D....
The goal of having computers automatically solve problems is central to artificial intelligence, machine learning, and the broad area encompassed by what Turing called ‘machine intelligence’ [384]. Machine learning pioneer Arthur Samuel, in his 1983 talk entitled ‘AI: Where It Has Been and Where...
Muscle mass is among the most relevant factors of this adaptation and, not by chance, often becomes a parameter to assess, even visually, the overall health or disease status of individuals. It depends on a complex balance between protein synthesis and degradation. These processes are regulated ...