of Prediction of Protein StructureGeneral principlesPacking order and Anfinsen's dogmaApplication to parathyroid-hormone-related protein (residues 1–34), abbreviated as PTHrP(1–34)#General principles#Packing order and Anfinsen's dogma#Application to parathyroid-hormone-related protein (residues 1–34)...
The folding types of 135 proteins, the three-dimensional structures of which are known, were analyzed in terms of the amino acid composition. The amino acid composition of a protein was expressed as a point in a multidimensional space spanned with 20 axes, on which the corresponding contents ...
Here, we investigate the folding of the maltose binding protein (MBP), a monomeric ~42 kDa two-domain protein comprised of a discontinuous N-terminal domain (NTD) and a C-terminal domain (CTD) (Fig.1a). The double mutation V8G/Y283D in the NTD20has been shown to significantly slow ...
Regulated unfolding: a basic principle of intraprotein signaling in modular proteins. Trends Biochem. Sci. 38, 538–545 (2013) Article CAS PubMed Google Scholar Sonenberg, N. & Hinnebusch, A. G. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136, ...
2024 年 8 月,康涅狄格大学的一项新研究揭示了一种先进的计算模型和工具,能够准确预测蛋白质的动态特征及其结晶倾向,相关研究成果以「Protein dynamics inform protein structure: An interdisciplinary investigation of protein crystallization propensity」为题发表在材料科学领域期刊 Matter 上。研究的重点在于蛋白质的自然运...
The crystal structure of one WD-repeat protein (G beta) has now been solved (Wall et al., 1995; Sondek et al, 1996) and reveals that the seven repeating units form a circular, propeller-like structure with seven blades each made up of four beta strands. It is very likely that all ...
As hypothesized by Li et al., there is a designability principle underlying nature's selection of protein folds (15), and this principle implies that the βαβ fold may exist as an independent structure. However, to our knowledge, the stand-alone form of the βαβ motif has never been...
The beta-trefoil proteins have little sequence similarity (sometimes less than 17%) and bind a range of molecules, including other proteins, DNA, membranes and carbohydrates. Protein folding experiments have been performed on four of the beta trefoils, namely, interleukin-1 (IL1B), acidic and ...
The Bam complex promotes the insertion of β-barrel proteins into the bacterial outer membrane, but it is unclear whether it threads β-strands into the lipid bilayer in a stepwise fashion or catalyzes the insertion of pre-folded substrates. Here, to dis
aeverything is beautiful bu t beautiful is not every everything is beautiful bu t beautiful is not every [translate] a蛋白质的折叠的研究是生命科学领域的前沿课题之一[1]。 The protein fold research is of (1) life sciences domain front topics.[translate]...