Baldwin RL ( 1995 ) The nature of protein folding pathways. The classical versus the new view . J Biomol NMR , 5 , 103 – 109 .Baldwin R. L. (1995) J. Biomolec. NMR 5:103–109Baldwin, R.L. 1995 . The nature of protein folding pathways: the classical versus the new view . J...
The nature of protein folding pathways: the classical versus the new view. ... RL Baldwin - 《Journal of Biomolecular Nmr》 被引量: 407发表: 1995年 The nature of protein folding pathways: the classical versus the new view. Journal of Biomolecular NmrBaldwin RL ( 1995 ) The nature of ...
Nature Reviews Molecular Cell Biology5,781–791 (2004)Cite this article 8994Accesses 7Altmetric Metrics Key Points In the cytosol of prokaryotes and eukaryotes, networks of molecular chaperones can assist polypeptides at all stages of folding. ...
In the cell, as in vitro, the final conformation of a protein is determined by its amino-acid sequence. But whereas some isolated proteins can be denatured and refolded in vitro in the absence of other macromolecular cellular components, folding and asse
The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge1,2,3,4,5. Here we describe a general solution to this problem that starts with a broad exploration of th...
In the absence of infection or apoptotic DNA damage, these pathways are typically silent, but under neuronal stress, TLR9 responds to the release of mitochondrial DNA fragments21. To determine whether extranuclear dsDNA fragments with TLR9-activating potential can be found in hippocampal neurons, we...
Probing the Nature of Noncovalent Interactions by Mass Spectrometry: A Study of Protein–CoA Ligand Binding and Assembly J. Am. Chem. Soc, 118 (1996), pp. 8646-8653 View in ScopusGoogle Scholar 24 G. Siuzdak, B. Bothner, M. Yeager, C. Brugidou, C.M. Fauquet, K. Hoey, C.M. Chan...
If the folding of the protein from U to N necessarily occurs via the intermediate, I is called an on-pathway intermediate (pathway III). Intermediates corresponding to the N↔U↔I (pathway I) and U↔N↔I pathways (pathway II) are off-pathway intermediates. Magenta dotted lines ...
et al. Probing the chemistry of thioredoxin catalysis with force. Nature 450, 124–127 (2007). Article CAS PubMed PubMed Central Google Scholar Schönfelder, J., De Sancho, D. & Perez-Jimenez, R. The power of force: insights into the protein folding process using single-molecule force...
They were informed of the nature of the study and its objectives and advised of participants’ confidentiality and anonymity. To make participants feel comfortable, they were allowed to withdraw from the study at any time and for any reason. All participants evaluated the tested products objectively...