C. Levinthal Are there pathways for protein folding J. Chim. Phys. Physico-Chemie Biol., 65 (1968), pp. 44-45 CrossrefGoogle Scholar 3 J.D. Bryngelson, J.N. Onuchic, et al., P.G. Wolynes Funnels, pathways, and the energy landscape of protein folding: a synthesis Proteins, 21 (...
Because of its importance to protein stability and function, it is important to understand the factors that influence the susceptibility of methionines to oxidation. There have been a number of published studies that have investigated factors that drive methionine oxidation (25, 28, 29, 30, 31, ...
Are there pathways for protein folding? Denatured proteins, which have had essentially all of their native three-dimensional structure disrupted, can refold from their random disorderd state into... C Levinthal - Journal de Chimie Physique et de Physico-Chimie Biologique...
It is well known that metabolism underlies T cell differentiation and functions. The pathways regulating T cell metabolism and function are interconnected, and changes in T cell metabolic activity directly impact the effector functions and fate of T cell
Protein-protein interactions are at the heart of all cellular processes, with the ribosome emerging as a platform, orchestrating the nascent-chain interplay dynamics. Here, to study the characteristics governing co-translational protein folding and complex assembly, we combine selective ribosome profiling...
To be disordered or not to be disordered: is that still a question for proteins in the cell? Article 13 June 2017 Main Intrinsically disordered proteins and protein regions (IDPs) play key roles in many cellular pathways and are vital to cellular function in all kingdoms of life1. Compared...
there are some interesting exceptions. For instance, in some cases, protein kinase is present between squalene synthase and phytoene desaturase. Similarly, although the DEAD helicase is conserved and present in most species, its position varies among species. In rare cases, genes such as protein ...
Nrf2/Keap1/ARE has been reported to orchestrate downstream oxidative mechanisms, which in turn regulate several inflammatory and apoptotic pathways [3]. The Nrf2/Keap1 pathway plays a crucial role in the regulation of genes responsible for antioxidant and cytoprotective functions. Nrf2, a transcription...
Protein-protein interactions are at the heart of all cellular processes, with the ribosome emerging as a platform, orchestrating the nascent-chain interplay dynamics. Here, to study the characteristics governing co-translational protein folding and complex assembly, we combine selective ribosome profiling...
Thus, there appears to be a counterintuitive trend between thermal stability or predicted CLIP affinity and intrinsic CLIP off-rate for polymorphisms in the P1 pocket, as polymorphisms leading to faster off-rates still come along with higher thermal stability. ...