Cell fate decisions are controlled by complex intracellular molecular regulatory networks. Studies increasingly reveal the scale of this complexity: not only do cell fate regulatory networks contain numerous positive and negative feedback loops, they also involve a range of different kinds of nonlinear ...
Collective cell migration offers a rich field of study for non-equilibrium physics and cellular biology, revealing phenomena such as glassy dynamics, pattern formation and active turbulence. However, how mechanical and chemical signalling are integrated at the cellular level to give rise to such collec...
We consider the ‘design type’ as a system that has been engineered, consisting of a single genotype. The design type could be any biosystem capable of evolution: a protein, genetic circuit, virus, cell, animal, plant or even an ecosystem. We introduce the concept of the ‘evotype’ to...
-Joey - after Salvatore's death he became addicted to cocaine and became the leader of the Leones. Increasingly paranoid, he made many messed up decisions, including getting into the SPANK trade, sealing an alliance with a Yakuza offshoot (I should mention, the Yakuza also had a period of ...
structure. Resonance theory holds that if classical theory allows a given compound several structures that satisfy the requirements of valence, then the actual state of the molecules of this compound will correspond not to any single structure but rather to some combination, or hybrid, of structures...
The Cosmic Inflation Theory was born as an extension of the Big Bang Theory to explain how the Universe was created and how everyone and everything got here. Explore the development of and evidence for the Cosmic Inflation Theory in this lesson. ...
a别把我当玩笑 Me do not work as joke [translate] a凡是越近 缘分势必早尽 Every will be a nearer fate inevitably early [translate] aKidney theory of TCM and the stem cell especially 肾脏理论的TCM和干细胞特别是 [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译 ...
Thus, ROS generated by perturbed mitochondria determins the fate of cells and tissues. ROS and/or NO impaires DNA in symbiotic bacteria and their hosts; the former enhances the mutation that accelerates their evolution while the latter enhances the process of aging and carcinogenesis. Based on ...
Therefore, telomere length is believed to be a determinant of the number of cell divisions and is thus a factor in aging and lifespan [6]. However, telomeres are shortened with age and affect the process of aging because they are regenerated with each replication, but not completely. More ...
Active DNA demethylation promotes cell fate specification and the DNA damage response. Science 378, 983–989 (2022). Article CAS PubMed PubMed Central Google Scholar Gill, D. et al. Multi-omic rejuvenation of human cells by maturation phase transient reprogramming. Elife 11, e71624 (2022). ...