Cell fate decisions are controlled by complex intracellular molecular regulatory networks. Studies increasingly reveal the scale of this complexity: not only do cell fate regulatory networks contain numerous positive and negative feedback loops, they also involve a range of different kinds of nonlinear ...
Collective cell migration offers a rich field of study for non-equilibrium physics and cellular biology, revealing phenomena such as glassy dynamics, pattern formation and active turbulence. However, how mechanical and chemical signalling are integrated at the cellular level to give rise to such collec...
Active DNA demethylation promotes cell fate specification and the DNA damage response. Science 378, 983–989 (2022). Article CAS PubMed PubMed Central Google Scholar Gill, D. et al. Multi-omic rejuvenation of human cells by maturation phase transient reprogramming. Elife 11, e71624 (2022). ...
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Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage. Molecular Biology of the Cell. 2016; 27:... Ana,Finzel,Andrea,... - 《Molecular Biology of the Cell》 被引量: 16发表: 2016年 加载更多来源...
only a small portion of cells can give rise to a new whole organism, those derived from cells ‘sequestered’ early in development for the production of sex cells. The other ‘somatic’ cells can reproduce at the cell level, but they cannot (at least naturally) give rise to a propagule ...
2002, Journal of Computational Biology The biochemical basis of an all-or-none cell fate switch in xenopus oocytes 1998, Science Cyclin-dependent kinases: Engines, clocks, and microprocessors 1997, Annual Review of Cell and Developmental Biology View all citing articles...
structure. Resonance theory holds that if classical theory allows a given compound several structures that satisfy the requirements of valence, then the actual state of the molecules of this compound will correspond not to any single structure but rather to some combination, or hybrid, of structures...
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel Uri Alon Ethics declarations Competing interests The author declares no competing financial interests. Related links FURTHER INFORMATION Uri Alon laboratory
cell, animal, plant or even an ecosystem. We introduce the concept of the ‘evotype’ to capture the evolutionary properties of that system. The evotype is a set of evolutionary dispositions of the design type, analogous to genotype and phenotype being sets of genes and traits, respectively ...