Cell cycle and cell fate in the nervous system. Curr Opin Neurobiol 2001; 11: 66-73S. Ohnuma, A. Philpott, W.A. Harris, Cell cycle and cell fate in the nervous system, Curr. Opin. Neurobiol. 11 (2001) 66-73.Ohnuma S,Philpott A,Harris WA.Cell cycle and cell fate in the nervous...
Cell division and the nervous system: Regulating the cycle from neural differentiation to death It has long been recognized that the balance between cellular proliferation and cell death during embryogenesis is a key factor in formation of the CNS. Th... ME Ross - 《Trends in Neurosciences》 被...
Pluripotent and neural stem cells have a short G1 cell cycle phase. Committed cells extend their G1 phase and cell cycle length. Stem cells initiate fate decisions by activating developmental genes in G1 phase. In pluripotent stem cells, developmental genes are cell cycle regulated and respond ...
It has long been proposed that the cell cycle is regulated by physical forces at the cell–cell and cell–extracellular matrix (ECM) interfaces1–12. However, the evolution of these forces during the cycle has never been measured in a tissue, and whether
Cell cycle and cell fate interactions in neural development FedericoCremisi, ...Shin-ichiOhnuma, inCurrent Opinion in Neurobiology, 2003 An asymmetric mode of cell division is a common strategy for the building of stratified neuronal architectures (Figure 2). In these structures, distinct cell types...
Specifically, we started from an analysis of how cell cycle transitions and cell fate are controlled in single cells, then to extend into the domain of how cells replicate in organisms and in disease. The topic is very broad. We were therefore forced to focus on a subset of particularly ...
也就是同时测量cell fate and cell state。 同时,另外一种研究范式是phylogenetic lineage reconstruction methods或者叫retrospective lineage tracing, 他是从后往前去构建细胞的发育轨迹,基于phylogenetic reconstruction of endogenous genetic polymorphisms (that is, no experimental intervention). 从后往前mapped backward...
Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure the production of two genetically identical cells. Cell cyc
Single-cell RNA sequencing allows us to model cellular state dynamics and fate decisions using expression similarity or RNA velocity to reconstruct state-change trajectories; however, trajectory inference does not incorporate valuable time point information or utilize additional modalities, whereas methods th...
1.PolyloxExpressbarcoding jointly uncovers stem cell fate and single-cell transcriptome 2.Multilineage and myelo-erythroid-restricted HSC clones dominate 3.A subset of HSCs does not differentiate; differentiation-inactive HSCs are not quiescent(和前人认识的不同) ...