Chromatin is the physical representative of the epigenome. Histones are the main protein component of chromatin and form octamer cores, around which genomic DNA is wrapped. These nucleosomes are the regularly repeating units of chromatin, but they can vary from one genomic region to the other by...
The structure of the ‘30 nm’ chromatin fibre has eluded us for 30 years and remains a major unsolved problem in biology. Progress during the past year has led to the proposal of two significantly different models: one derived from the crystal structure of a four-nucleosome core array ...
Related to Chromatin structure:nucleosome chro·ma·tin (krō′mə-tĭn) n. A complex of nucleic acids and proteins, primarily histones, in the cell nucleus that stains readily with basic dyes and condenses to form chromosomes during cell division. ...
INTRODUCTIONAlleukaryoticchromosomesconsistsofaregularlyrepeatingprotein--DNAcomplexcalledthenucleosome(Kornberg,1977)[if.Itistraditionallyconsideredtobethefundamentalunitofchromatinstructure.Thephysicalpropertiesofnucleosomedependonsolutioncondition...关键词: Nucleosome core particle chicken erythrocytes atomic force microscopy...
Within the promoter regions of both major histocompatibility complex (MHC) class I genes and the 2 -microglobulin (2m) gene, there are a number of common regulatory elements suggesting co-ordinate control. However, there is also evidence to suggest that 2m and class I are differentially regulated...
Structure of the chromatosome, a chromatin particle containing 160 base pairs of DNA and all the histones Structure of the chromatosome, a chromatin particle containing 160 base pairs of DNA and all the histonesAnimalsErythrocytesCell NucleusChromatin... RT Simpson - 《Biochemistry》 被引量: 1236...
Structures can occur in coding or non-coding RNAs, and learning more about RNA structure will improve our understanding of the transcriptome. Computational predictions of RNA structures have been important and continue to be refined and also combined with experimental methods. Experimental methods, which...
We conclude that, overall, non-CpG mutation rates are lowest in open regions of the genome and that regions of the genome with a closed chromatin structure have the highest background mutation rate. This might reflect lower rates of DNA damage or enhanced DNA repair processes in regions of op...
A tightly regulated balance between self-renewal and differentiation of cells is critically important for the normal homeostasis of organisms. Cells of the blood lineage are particularly highly reliant on this balance to sustain the hierarchical structure of the hematopoietic system, which gives rise to...
The structure ... M.J. Saunders,E Yeh,M Grunstein,... - 《Molecular & Cellular Biology》 被引量: 125发表: 1990年 Intra- and inter-nucleosome interactions of the core histone tail domains in higher-order chromatin structure Eukaryotic chromatin is a hierarchical collection of nucleoprotein ...