For decades, we tacitly assumed that the components of such complex systems as the cell, the society, or the Internet are randomly wired together. In the p... Barabási,Albert-László - 《Science》 被引量: 1501发表: 2009年 Global protein function prediction from protein-protein interaction ne...
If the integrity of PML bodies are lost in the NB4 cell line due to the association of the PML-RARαfusion protein with RARαtarget genes, we are interested in possibility that these relatively intact bodies represent a "gene hub", whereby PML body components are retained through ...
The list of targets is enriched for factors that direct SUMOylation and for nuclear proteins involved in chromatin remodeling/repair, transcription, RNA metabolism, and protein trafficking. Targets of particular interest include histone H2B, components in the LEUNIG/TOPLESS corepres-sor complexes, and...
Chronic lymphocytic leukaemia (CLL) is characterized by substantial clinical heterogeneity, despite relatively few genetic alterations. To provide a basis for studying epigenome deregulation in CLL, here we present genome-wide chromatin accessibility map
S7), represent the essential functional components of commonly co-expressed proteins (Additional file 1: Fig. S8; Table S5). The PCPIC cores showed distinct differential protein expression patterns, dependent on cancer types (Fig. 1F; Additional file 1: Supplemental Results), and constituted a ...
We mined our data for gene knockouts that enriched in culture and identified many genes, including components of the TP53 pathway and other known tumor suppressors. We validated the strongest hit, PMAIP1/NOXA, which appears to be a stem cell-specific gene conferring sensitivity to DNA damage ...
Previous epigenome-wide association studies (EWAS) have emphasized the epigenetic role of lipid metabolism as a major contributor to the pathogenesis of MetS and its phenotypic outcomes. [1, 2] Both obesity [3, 4] and hypertension [5], as components of MetS, have also been reported to be ...
The colors of variants are based on their LD with the most significant eVariant. e The proportion of eQTLs (y-axis) with chromatin states using fine mapping eVariants, top significant eVariants and total eVariants. f Distribution of cis-H2. The solid line corresponds to all tested genes, ...
and form the components of the translocon that secretes other GRAs into the host cytoplasm. It is therefore likely that these PVM-localized GRAs and the putative chaperones that mediate the correct trafficking of these GRAs to the PVM will be important for parasite fitness in IFNγ-activated ...
A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping. Cell 159, 1665–1680 (2014). Article CAS PubMed PubMed Central Google Scholar Smemo, S. et al. Obesity-associated variants within FTO form long-range functional connections with IRX3. Nature 507, ...