Two protein–protein interaction networks are shown: androgen receptor binding (for WT) and structural constituent of the nuclear pore (for 22YtoS). The line thickness corresponds to the strength of published data supporting the interaction, generated from STRING (string-db.org). Additional GO ...
This study was one of the first to demonstrate that loss of a single gene (TBX1) within a larger genomic disorder CNV locus (22q11.2 deletion) is individually associated with one of the constituent phenotypes commonly observed in CNV carrier patients, which provided important empirical evidence ...
Nurk, S. et al. The complete sequence of a human genome.Science376, 44–53 (2022).This seminal publication from the T2T consortium describes the first complete (gapless) sequencing of a single human genome, which marks the beginning of the era of complete human genomes and pangenome graphs...
The overall structure relates to the cooperative interactions and interdependency of the constituent sub-complexes of the CCAN. The duplex DNA is topologically entrapped by human CCAN. Further, CENP-N does not bind to the RG-loop of CENP-A but to DNA in the CCAN complex. The DNA binding ...
Nuclear matrix and heterogeneous nuclear ribonucleoprotein (hnRNP) were compared to establish whether premessenger RNA (premRNA) was associated with a same constituent in both structures. The isolation of nuclear matrix included the removal of chromatin and of 0.4 M KCl-soluble material. HnRNP, ...
In our database, most categories describe the structure of LCRs (tertiary structure, disordered region, helix, secondary structure, coiled-coil, structure, structural constituent of ribosome). There are also annotations of binding regions or nucleotides (RNA, DNA, ATP, GTP binding), ions and prote...
regions the total ChIP-seq signal in the region was quantified and is displayed in the top right corner of the plot for each metagene analysis. The number of elements surveyed is listed at the top of the plot. Both plots are floored at the minimum amount of typical enhancer constituent ...
extremely rapid cessation of its synthesis (Figure S4). To avoid pulling out newly formed NPCs, a non-exchanging NPC constituent is required (Figure S1B). We chose Nup84 (a representative of the outer ring) and Nup157 (a representative of the inner ring) because homologs of these Nups ...
Structural basis for the recognition of lysozyme by MliC, a periplasmic lysozyme inhibitor in Gram-negative bacteria Lysozymes are an important component of the innate immune system of animals that hydrolyze peptidoglycan, the major bacterial cell wall constituent. Many b... S Yum,MJ Kim,Y Xu,...
Meiotic chromosomes adopt unique structures in which linear arrays of chromatin loops are bound together in homologous chromosome pairs by a supramolecular protein assembly, the synaptonemal complex. This three-dimensional scaffold provides the essential structural framework for genetic exchange by crossing ov...