Two protein–protein interaction networks are shown: androgen receptor binding (for WT) and structural constituent of the nuclear pore (for 22YtoS). The line thickness corresponds to the strength of published data supporting the interaction, generated from STRING (string-db.org). Additional GO ...
Correct chromosome segregation relies on the centromere, a specialized chromatin domain present throughout the cell cycle that acts as a platform on which transient assembly of the kinetochore occurs during mitosis1,2. In eukaryotic cells, kinetochores, which are sophisticated molecular machines for cell...
In the model yeast (Saccharomyces sp.), the 52-MDa NPC is composed of 30 different proteins, called nucleoporins or Nups, present as a total of ∼550 subunits. Its functions, constituent protein subunits, and three-dimensional architecture have been characterized in high detail, and its ...
In [29], mass spectrometric identification of differential proteins between low methionine-fed chickens and high methionine fed-chickens revealed the differential regulation of various isoforms of actin: ACTA1 (major constituent of the contractile apparatus), ACTB and ACTG1 (involved in the regulation...
The overall structure relates to the cooperative interactions and interdependency of the constituent sub-complexes of the CCAN. The duplex DNA is topologically entrapped by human CCAN. Further, CENP-N does not bind to the RG-loop of CENP-A but to DNA in the CCAN compl...
We have investigated the structure of ... CH Duncan,P Jagadeeswaran,RRC Wang,... - 《Gene》 被引量: 194发表: 1981年 Nuclear matrix and hnRNP share a common structural constituent associated with premessenger RNA. Nuclear matrix and heterogeneous nuclear ribonucleoprotein (hnRNP) were compared ...
During cell division hNMP 200 became irregularly distributed in prophase, sparing regions of condensing chromatin. In anaphase it was concentrated in the spindle midzone. The putative dual function of the novel NMP is discussed. Being a component of the nuclear framework, it may provide structural ...
A nucleosome is the fundamental repeating unit of the eukaryotic chromosome. It has been shown that the positioning of a majority of nucleosomes is primarily controlled by factors other than the intrinsic preference of the DNA sequence. One of the key qu
This higher level of chain folding is governed by the topology of the constituent nucleosomes and the spatial disposition of the intervening protein-free DNA linkers. Results: By simplifying the protein-DNA assembly to an alternating sequence of virtual bonds, the organization of a string of ...
Meiotic chromosomes adopt unique structures in which linear arrays of chromatin loops are bound together in homologous chromosome pairs by a supramolecular protein assembly, the synaptonemal complex. This three-dimensional scaffold provides the essential structural framework for genetic exchange by crossing ov...