In this work the possibility of its structural and functional homology to the high mobility group 1 (HMG1) nonhistone protein constituent of chromatin was examined. The results of two-dimensional gel electrophoresis, Southwestern and Western immunoblot analyses, showed that p29 and HMG1 are ...
Two protein–protein interaction networks are shown: androgen receptor binding (for WT) and structural constituent of the nuclear pore (for 22YtoS). The line thickness corresponds to the strength of published data supporting the interaction, generated from STRING (string-db.org). Additional GO ...
Meiotic chromosomes adopt unique structures in which linear arrays of chromatin loops are bound together in homologous chromosome pairs by a supramolecular protein assembly, the synaptonemal complex. This three-dimensional scaffold provides the essential structural framework for genetic exchange by crossing ov...
In [29], mass spectrometric identification of differential proteins between low methionine-fed chickens and high methionine fed-chickens revealed the differential regulation of various isoforms of actin: ACTA1 (major constituent of the contractile apparatus), ACTB and ACTG1 (involved in the regulati...
Given its role in membrane modulation and the fact that SMPDL3B is anchored to the membrane via a glycosylphosphatidylinositol link (7), its substrate is likely to be a membrane constituent like SM. The substrate and function of SMPDL3A, however, are less clear. This enzyme is secreted by ...
The overall structure relates to the cooperative interactions and interdependency of the constituent sub-complexes of the CCAN. The duplex DNA is topologically entrapped by human CCAN. Further, CENP-N does not bind to the RG-loop of CENP-A but to DNA in the CCAN compl...
In mitosis, accurate chromosome segregation depends on kinetochores that connect centromeric chromatin to spindle microtubules. The centromeres of budding yeast, which are relatively simple, are connected to individual microtubules via a kinetochore cons
it is likely that the proportional relationship between exonic sequence and expression effect is at least in part due to the use of constituent gene products and future use of isoform level expression should provide more specificity of SV effect. We also leverage assumptions about the direction of...
Thermal stabilities of brain spectrin and the constituent repeats of subunits Biochemistry, 45 (2006), pp. 13670-13676 Google Scholar [32] D.E. Discher, P. Carl New insights into red cell network structure, elasticity, and spectrin unfolding—a current review Cell. Mol. Biol. Lett., 6 (20...
the stability of the constituent proteins should also increase, leading to the stabilization of the whole complex, thereby allowing proper functioning. Problems might occur if a mutation in a partner protein increases the binding affinity but decreases its stability. This would mean that the interactio...