Here, we present in-depth the involvement of bile acids in oesophageal, gastric, hepatocellular, pancreatic, colorectal, breast, prostate, ovarian cancer. Previous studies often used bile acids in supraphysiological concentration, sometimes in concentrations 1000 times higher than the highest reported ...
Serum levels of bile acids in pancreatic cancer patients and the effect of serum on Capan-1 cells. (A) Serum levels of bile acids (BAs) in healthy volunteers and pancreatic ductal adenocarcinoma patients (PDAC) with or without obstructive jaundice (OJ) were measured by LC–MS. GCA glycocholic...
The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science 342, 971–976 (2013). Article CAS PubMed PubMed Central Google Scholar Delaney, G., Jacob, S., Featherstone, C. & Barton, M. The role of radiotherapy in cancer treatment: estimating optimal ...
Therefore, the aim of this systemic review is to summarize the current literature focusing on the proportions and distribution, molecular pathogenesis, prognostic significance of TILs and their role in immunotherapy for CCA patients. In CCA, CD8+ and CD4+ T lymphocytes represent the majority of ...
FXR, in addition to its essential role in cholesterol/BA metabolism, also contributes to triacylglycerol (Fuchs et al. 2013) and glucose metabolism. In fact, BA, via activation of FXR present in pancreatic β cells, are capable of stimulating insulin production (Schittenhelm et al. 2015). Fu...
Bile Acid Analysis in Biliary Tract Cancer The etiology of biliary tract cancer is obscure, but there are evidences that bile acid plays a role in carcinogenesis. To find the association between bil... JY Park,BK Park,JS Ko,... - 《Yonsei Medical Journal》 被引量: 122发表: 2006年 Bilia...
This functional role of exosomes in cancer development, as well as their ability to be easily isolated from bodily fluids such as serum, makes them an attractive candidate for biomarker development. In addition, more recently, there has been a growing interest in the therapeutic manipulation of ...
However, the mechanisms underlying the therapeutic effects of TCMs are still unclear. Recent clinical trials have confirmed that microbial mediation possibly plays an important role in the therapeutic effects of TCMs [20,21]. In particular, the gut microbiota may improve the bioavailability and ...
Single-cell RNA sequencing can reveal valuable insights into cellular heterogeneity within tumour microenvironments (TMEs), paving the way for a deep understanding of cellular mechanisms contributing to cancer. However, high heterogeneity among the same
Also, the crucial role of cysteine cathepsins B, L, and S in neovascularization in pancreatic cancer has been described [25, 26]. While these changes to the lysosome may grant some advantages to the tumor cell, the elevated levels in damaging cathepsin activity and decreased levels of ...