and Moschetta, A.: Bile acids and colon cancer: Solving the puzzle with nuclear receptors. Trends Mol. Med., 17: 564-572 (2011).Degirolamo C, Modica S, Palasciano G, Moschetta A. Bile acids and colon cancer: Solving the puzzle with nuclear receptors. Trends in molecular medicine. 2011...
Bile acids, fibre and colon cancer: the story unfolds Are the changes in faecal bile acid concentrations the cause of colorectal cancer or one of its effects? This is an area of controversy mainly due to the l... MF Chaplin - 《Journal of the Royal Society of Health》 被引量: 97发表...
Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood. We hypothesize that the cytotoxic bile acids may...
Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood.
In humans, BAs are largely re-absorbed in the terminal ileum by an active transport mechanism, but less than 5% of the BA pool enters the colon per day[12]. The BAs that enter the colon are metabolized by bacterial flora, where the primary BAs (cholic and chenodeoxycholic acid) are ...
a3.1 Decisions and management level 3.1决定和管理级别 [translate] a3.2Information characteristics by management level 3.2Information特征由管理级别 [translate] aIt is known that bile acid is an intrinsic promoter of colon cancer. Azumaet 它知道胆汁酸是结肠癌的一个内在促进者。 Azumaet [translate] ...
Bile acid distributions, sex-specificity, and prognosis in colorectal cancer Background Bile acids (BAs) belong to cholesterol-derived sterols. Due to the side chain carboxyl group and hydroxylation of their steroid ring they are more polar than cholesterol. They have an amphipatic character for ...
Lithocholic acid and sulphated lithocholic acid differ in the ability to promote matrix metalloproteinase secretion in the human colon cancer cell line CaCo-2 The human colon carcinoma cell line CaCo-2 has the ability to sulphate the secondary bile acid lithocholic acid (LA), whereas other primary...
This work investigated the mechanisms involved in bile acid (deoxycholic acid (DCA))-induced intestinal epithelial cell monolayer permeabilization and the preventive capacity of (-)-epicatechin (EC). While EC prevented high fat diet-induced intestinal permeabilization in mice, it did not mitigate the...
Bile acid (BA)-activated nuclear receptors maintain BA homeostasis by regulating BA metabolism and transport within the enterohepatic circulation. BAs and their nuclear and G protein-coupled receptors also control lipid and/or glucose and energy homeostasis, inflammation and fibrosis as well as cell pr...