Bile acids and colon cancer:Is FXR the solution of the conundrum?. Gadaleta RM,Garcia-Irigoyen O. Molecular Aspects of Medicine . 2017Gadaleta, R. M., Garcia-Irigoyen, O., & Moschetta, A. (2017). Bile acids and colon cancer: Is FXR the solution of the conundrum?. Molecular Aspects ...
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Although the unconjugated secondary bile acids, specifically deoxycholic acid (DCA) and lithocholic acid (LCA), are considered to be risk factors for colorectal cancer, the precise mechanism(s) by which they regulate carcinogenesis is poorly understood. We hypothesize that the cytotoxic bile acids may...
C. et al. Physical activity as a determinant of fecal bile acid levels. Cancer Epidemiol. Biomark. Prev. 18, 1591–1598 (2009). Article CAS Google Scholar Danese, E. et al. Middle-distance running acutely influences the concentration and composition of serum bile acids: potential ...
Disruption of bile acid–microbiota crosstalk promotes inflammation and a gastrointestinal disease phenotype, which can contribute to the development of gastrointestinal cancers, including colorectal cancer and hepatocellular carcinoma The modulation of gut microbiota and bile acid profiles holds promise as a ...
which can be used to detoxify LCA in the liver and intestine (Ridlon et al., 2006; Makishima et al., 2002). In addition, high accumulation of DCA in bile acid pool in human body is thought to be associated with cholesterolgallstone diseaseandcolon cancer(Nagengast et al., 1995; Hussaini...
a3.1 Decisions and management level 3.1决定和管理级别[translate] a3.2Information characteristics by management level 3.2Information特征由管理级别[translate] aIt is known that bile acid is an intrinsic promoter of colon cancer. Azumaet 它知道胆汁酸是结肠癌的一个内在促进者。 Azumaet[translate]...
Dietary fiber has direct effects on stool bulk and bile acid output that may be of relevence in the etiology of colon cancer. Most types of fiber increase the total volume of stool and reduce the concentration of specific substances, including bile acids, that are in contact with the bowel ...
Kühn T, Stepien M, López-Nogueroles M, Damms-Machado A, Sookthai D, Johnson T, Roca M, Hüsing A, Maldonado SG, Cross AJ. et al. Prediagnostic plasma bile acid levels and colon cancer risk: a prospective study.J Natl Cancer Inst. 2020;112(5):516–24. doi:10.1093/jnci/djz166...
The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), is involved in the pathophysiology of a wide range of diseases of gastrointestinal tract, including inflammatory bowel disease, colorectal cancer and type 2 diabetes. In this review, authors discuss current knowledge of the roles...