The role of bile acids in carcinogenesis. Mutat Res 2001; 480-481: 359-369Debruyne PR,Bruyneel EA,Li X ,et a1.The role of bile acids in carcinogenesis.Mutat Res,2001,480481:359-369.Debruyne PR, Bruyneel EA, Li X, Zimber A, Gespach C, Mareel MM. The role of bile acids in ...
Role of bile acids in carcinogenesis of pancreatic cancer: An old topic with new perspective. World J. Gastroenterol. 22, 7463–7477. https://doi.org/10.3748/wjg.v22.i33.7463 (2016). Article CAS PubMed PubMed Central Google Scholar Lu, Y. et al. The cytotoxic effects of bile acids ...
accumulating evidence has clarified the complex role of the human microbiota in the development of cancer and the therapeutic response. More importantly, available evidence seems to indicate that modulating the composition of the gut microbiota to improve the efficacy of anti-cancer drugs may be ...
The mechanisms contributing to the pathogenesis of I/R injury are multifactorial. Oxidative stress, inflammation, mitochondrial dysfunction, apoptosis, and protein kinases activation all play an important role in I/R-induced injury [58]. Recently, multiple studies have focused on the effects of PII ...
Therefore, the aim of this systemic review is to summarize the current literature focusing on the proportions and distribution, molecular pathogenesis, prognostic significance of TILs and their role in immunotherapy for CCA patients. In CCA, CD8+ and CD4+ T lymphocytes represent the majority of ...
The gut microbiota plays a critical role in the progression of human diseases, especially cancer. In recent decades, there has been accumulating evidence of the connections between the gut microbiota and cancer immunotherapy. Therefore, understanding the
1 To further confirm this, we analyzed Opn mRNA expression in IECs of jejunum from wild-type (WT) mice fed control or ethanol Lieber-DeCarli (LDC) diet. Ethanol induced Opn mRNA expression in IECs (Figure 1, A). To evaluate the role of increased expression of OPN in IECs in ALD, ...
Although bile acids have been implicated in colon cancer development, their role in biliary tract carcinogenesis remains unexplored. Because receptor tyrosine kinases and cyclooxygenase (COX)-2 have been implicated in carcinogenesis, we examined the hypothesis that bile acids modulate these enzymes in K...
Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology. Nat. Rev. Gastroenterol. Hepatol. https://doi.org/10.1038/s41575-021-00566-7 (2022). Article PubMed Google Scholar Hamilton, J. P. et al. Human cecal bile acids: concentration and spectrum. Am. J. ...
Recently, the pilot roles of SIKs in tumorigenesis have begun to attract more attention due to the finding that the tumor suppressor role of LKB1 in non-small-cell lung cancers (NSCLCs) is unexpectedly mediated by the SIK but not AMPK kinases. Thus, here we tend to comprehensively summarize...