To test this possibility, we implemented a streamlined approach for the prediction and validation of such neoantigens derived from individual tumors and ... Mohini,Rajasagi,A Sachet,... - 《Blood》 被引量: 228发表: 2014年 The problem with neoantigen prediction Nature Biotechnology 35, 97 (2017...
Pipelines for neoantigen prediction are rapidly being built and optimized, and developments in NGS techniques and applications promise to address many of the existing issues in neoantigen prediction and speed up the development of effective cancer vaccines [11]. The current research has summarized the ...
which are strongly immunogenic and rapidly eliminated; restrained neoantigens, which are only recognized by T cells unleashed by ICIs; and ignored neoantigens, which are not immunogenic even with ICI therapy. Ignored neoantigens are presented on MHC class I complexes,...
CIN is often the result of errors in DNA replication, which can lead to the formation of cells with incomplete or excess genetic material; as well as errors in chromosome segregation during cell division, which can lead to the formation of cells with an abnormal number ...
Key parameters of tumor epitope immunogenicity revealed through a consortium approach improve neoantigen prediction Cell, 183 (2020), pp. 818-834.e13 View PDFView articleView in ScopusGoogle Scholar Wieder et al., 2018 T. Wieder, T. Eigentler, E. Brenner, M. Röcken Immune checkpoint blockade...
of MHC class I and subsequent treatment-responsive downregulation, resulting in impaired tumor antigen presentation and T cell anti-tumor immunity, which may be one of the reasons why SCLC tumors show limited T cell anti-tumor activity despite the presence of numerous potential neoantigens [51,52...
We also explored whether the 6-gene prognostic risk model was effective for survival prediction. In conclusion, the constructed a risk score model based on immune-related genes and the survival of patients with OS could be a potential tool for targeted therapy....
More importantly, recent studies have demonstrated dMMR/MSI-H is a predictive biomarker for immunotherapy, because dMMR/MSI-H CRCs are associated with a higher mutational burden tumor neoantigen load, and dense immune cell infiltration [6, 7]. In addition, immunotherapy in patients with advanced ...
However, just as not all solid tumors with high TMB are sensitive to ICTs, patients with high neoantigens do not necessarily have an elevated level of CD8+ T cell infiltration in the TME of ccRCC.45 Therefore, under a paradigm of targeted therapies, such as TKIs, two of the clusters ...
et al. MHC-II neoantigens shape tumour immunity and response to immunotherapy. Nature 574, 696–701 (2019). CAS PubMed PubMed Central Google Scholar Senovilla, L. et al. An immunosurveillance mechanism controls cancer cell ploidy. Science 337, 1678–1684 (2012). CAS PubMed Google Scholar ...