et al. Targeting a neoantigen derived from a common TP53 mutation. Science 371, eabc8697 (2021). Article CAS PubMed PubMed Central Google Scholar Cancer Genome Atlas Research Network. et al. The Cancer Genome Atlas pan-cancer analysis project. Nat. Genet. 45, 1113–1120 (2013). Article...
TP53andRB12,3, we sought to further characterize the transcriptional profile of SCLC in comparison to other major lung cancer subtypes. We therefore performed a comparative analysis with the transcriptome sequencing data of 214 patient-derived lung tumors2,...
Public neoantigens (NeoAgs) represent an elite class of shared cancer-specific epitopes derived from recurrently mutated driver genes. Here we describe a high-throughput platform combining single-cell transcriptomic and T cell receptor (TCR) sequencing to establish whether mutant, among the most freque...
a Mutations of KRAS occur in different types of cancers. Data derived from the AACR GENIE 9.0 public database. b Distribution of KRAS alleles in selected tumor types. The top 6 alleles with the highest overall disease rate are listed, while the other mutations were classified in the ‘other...
Cancer immunotherapies, represented by immune checkpoint inhibitors (ICIs), have reshaped the treatment paradigm for both advanced non-small cell lung cancer and small cell lung cancer. Programmed death receptor-1/programmed death receptor ligand-1 (PD-1
thereby augmenting the effectiveness of DC vaccination [114,182]. Additionally, a nanovaccine derived from rAd-infected mature DCs in which specific MHC-I, anti-PD1 antibody and B7 costimulatory molecules are simultaneously anchored can self-present neoantigens to T cells and stimulate strong CTL res...
a common pharmacophore, including bacterial natural products derived from fermentation ofPseudomonassp. or distinct species ofStreptomyces, and synthetic compounds. The three families of SF3b-targeting spliceosome modulators comprise spliceostatins (e.g. spliceostatin A, meayamycin, and sudemycins), ...
is derived from the p21 gene's promoter (WAF1), but it is unable to activate other response elements [66]. A growing body of research using a variety of models, including breast cancer cells, suggests that mutant p53 has specific transactivation and DNA-binding abilities. Hotspot p53 mutants...
Public neoantigens (NeoAgs) represent an elite class of shared cancer-specific epitopes derived from recurrently mutated driver genes. Here we describe a high-throughput platform combining single-cell transcriptomic and T cell receptor (TCR) sequencing to establish whether mutant, among the most ...
This study showed that in a subset of MCCs with a viral aetiology, neoantigens derived from viral proteins can serve as strong immune stimulants and may be an attractive target for cancer immunotherapy. PubMed Google Scholar Nghiem, P. T. et al. PD-1 blockade with pembrolizumab in ...