肝肺处肿瘤均发生缩小;在7个月后,肝处病灶处于无进展状态,而肺处病灶发生再次进展增大;随后,在第一次回输完成18个月后,为该患者进行第二次TIL治疗(ERBB2IP specific T cells含量提升到95%),回输后,肝肺病灶再次缩小并持续6个月。
首先,建立一个肿瘤细胞Panel——如图04A,免疫缺陷小鼠(129/Sv Rag2-/- mice)通过化学诱导产生肉瘤,将其体外分离获得肉瘤细胞系(H31m1 Sarcoma tumor cell line),进一步在体外有限稀释获得亚克隆细胞系(T1 ～T10)。此外,通过将H31m1及亚克隆细胞系接中回正常小鼠(129/Sv mice)后,依照小鼠肿瘤发生消退还是增大,...
The success of cancer immunotherapy depends in part on the strength of antigen recognition by T cells. Here, we characterize the T cell receptor (TCR) functional (antigen sensitivity) and structural (monomeric pMHC-TCR off-rates) avidities of 371 CD8 T cell clones specific for neoantigens, ...
In this work, we evaluate broadly the structural avidities and antigen sensitivities of neoantigen-specific T cells and ask whether these correlate with the cell aptitude for tumor infiltration and homing. We profile a large library of CD8 T cells specific for neoantigens, tumor-associated antigens...
Neoantigen-specific T cells for adoptive T cell therapies T cells play a major role in human immune response, and the ultimate purpose of a tumor vaccine is to activate and amplify tumor-specific T cells in vivo, so as to identify and kill tumor cells. T cell specific activation, ...
(MHC, or the human leukocyte antigen [HLA]) as a “non-self” neoantigen, and subsequently be recognized by specific TCRs to elicit T cell immune responses17. T cells specific for KRAS mutants would eliminate tumor cells with KRAS mutations through secreted cytokines or via direct killing ...
Neoantigen-Specific T Cells in Adoptive Cell Therapy 来自 Wolters Kluwer 喜欢 0 阅读量: 8 作者: E Tran 摘要: The holy grail of cancer therapeutics is the destruction of cancer cells while avoiding harm to normal cells. Cancer is unique from normal tissues because of the presence of somatic ...
Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer .Science. 2014 May 9;344(6184):641-5. doi: 10.1126/science.1251102. Immunogenicity of somatic mutations in human gastrointestinalcancers.Science.2015 Dec...
Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer. N Engl J Med. 2022;386(22):2112-2119. doi:10.1056/NEJMoa2119662 医学 生物 科学 知识 科学科普 生命 最热 最新 请先登录后发表评论登录发布 没有更多评论Johnson_Han 发消息
Title: Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells Pubication Data: 2014/03/27 Journal: Nature Protocols Note: Philip D Greenberg 当之无愧的免疫界大神 Title: Targeting of cancer neoantigens with donor-derived T cell receptor repertoires ...