What is tumor mutation load? Why does the immune repertoire matter? Cancer is a genetic disease with mutations that cause a change in regulatory processes causing cells to grow out of control and become invasive (1). Some o...
Neoantigens are a class of antigens that is completely foreign and absent in normal human tissues and cells while present exclusively on cancer cells. In contrast, oncoviral antigens are peptides expressed by virally associated tumors, such as oncoprotein E7 of human papillomavirus 16.26,27 ...
Despite recent major advances in developing effective vaccines against toxoplasmosis, finding new protective vaccination strategies remains a challenging and elusive goal as it is critical to prevent the disease. Over the past few years, various experimental approaches have shown that developing an effectiv...
G. Is it possible to develop cancer vaccines to neoantigens, what are the major challenges, and how can these be overcome? Neoantigens: nothing new in spite of the name. Cold Spring Harb. Perspect. Biol. https://doi.org/... Kissick,T Haydn - 《Cold Spring Harbor Perspectives in Biolo...
Haydn T. KissickCold Spring Harb Perspect BiolFinn, O.J.; Rammensee, H.-G. Is It Possible to Develop Cancer Vaccines to Neoantigens, What Are the Major Challenges, and How Can These Be Overcome? Neoantigens: Nothing New in Spite of the Name. Cold Spring Harb. Perspect. Biol. 2018,...
Immune evasion is considered to be one of the hallmarks of cancer and is an essential step in the evolution of a tumor [13]. Tumor-immune evasion is achieved through multiple mechanisms: (1) selective evolution of tumors with down-regulated expression of neoantigens; (2) decrease or loss of...
Small intestinal adenocarcinoma is the most common type of gastric cancer in Lynch individuals. Imamura et al. [47] found that MSI esophagogastric junction adenocarcinoma (EGJ) which is a special gastric cancer is closely related to genetic instability. And the researchers suggested that tumors in...
The structure can send signals leading to the activation of T cells; however, it did not support cell expansion, which is a necessary step for disease control. To overcome this issue, the second-generation CAR-T had a costimulatory signaling domain (e.g., CD28, 4-1BB, and OX40), ...
Multiple myeloma (MM) is a haematological malignancy characterised by the clonal proliferation of malignant plasma cells within the bone marrow [1]. It is a rare disease that accounts for approximately 80% of malignant monoclonal gammopathies and 15% of haematological malignancies. This pathology pre...
Indeed, in human lymphoblastoma-derived MCL-5 cells transfected with various human CYPs (hCYP), hCYP2B6 (and, to a lesser extent, hCYP2C8 and hCYP1A2) was able to catalyze the reaction of PERC to acetylated neoantigens, which were recognized by immunoreactivity to anti-trifluoroacetylated...