3, whether immunoediting occurs naturally in human cancers remains unclear. Here, to address this, we investigate how 70 human pancreatic cancers evolved over 10 years. We find that, despite
Neoantigen quality predicts immunoediting in survivors of pancreatic cancerIsraeli, EitanIsrael Medical Association Journal
pVACfuseis a part of pVACtools package. It predicts neoantigens produced specifically by gene fusion events. Here we are exploring how can we run the tool in house. The tool works with input generated by a fusion callerINTEGRATE. Unfortuantely, it's not documented, the code base is not su...
pVACfuseis a part of pVACtools package. It predicts neoantigens produced specifically by gene fusion events. Here we are exploring how can we run the tool in house. The tool works with input generated by a fusion callerINTEGRATE. Unfortuantely, it's not documented, the code base is not su...
Immunoediting A hypothesis that describes the transition between immune protection against tumour development and tumour outgrowth in three phases: elimination, equilibrium and escape. Antigenicity Immune responses induced by vaccination as in the case of ignored neoepitopes. Immunogenicity Induction of immune...
On the contrary, in the last few years, different studies carried out by others [62] have indicated that CD8 T cells have a great influence on the immunogenicity and the microenvironment through immunoediting, but these cells might not be the unique responsible for ICI response. This may be ...
(2011). Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331, 1565–1570. Schumacher, T.N., and Hacohen, N. (2016). Neoantigens encoded in the can- cer genome. Curr. Opin. Immunol. 41, 98–103. Schumacher, T.N., and Schreiber, R.D. ...
Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion Science, 331 (2011), pp. 1565-1570 Google Scholar Schumacher and Hacohen, 2016 T.N. Schumacher, N. Hacohen Neoantigens encoded in the cancer genome Curr. Opin. Immunol., 41 (2016), pp. 98-103 Google ...
Comparison to PDOs from pre-invasive MSS CRCs is desirable to assess whether they harbor higher neoantigen numbers than our PDOs from more advanced CRCs, which would indicate immunoediting as a mechanism of neoantigen loss [3, 39]. Our data contrasts with published data showing that neoantigen-...
Expression of tumour-specific antigens underlies cancer immunoediting. Nature 482, 405–409 (2012). Article CAS PubMed PubMed Central Google Scholar Gubin, M. M. et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515, 577–581 (2014). Article CAS ...