While HERVs might also act as auto-, super- or neoantigens (upon expression of oncogenic viruses), HERV variants could participate in antigenic mimicry, all of which have the potential to enhance inflammatory responses or induce autoimmune reactions [110]. However, HERV-W expression in ...
This observation of context-dependent predictiveness remains strong regardless of immune subtype (Immune-Enriched or Non-Immune), PD-L1 regulation mechanism (adaptative or constitutive), tumor mutation burden, or neoantigen load. This work illuminates avenues for optimizing the use of PD-L1 expression...
Available data on neoantigens for 77 TCGA-STAD samples were extracted (https://tcia.at/neoantigens) [62]. 4.7. Identification of Significantly Mutated Genes To assess the somatic mutation profiles of genes throughout the genome, we searched for genes that were mutated more frequently than ...