The mitogen-activated protein kinase (MAPK) cascade pathway mediates various signalling pathways associated with abiotic stress tolerance in plants. In this research, 15 MAPKs, 5 MAPKKs and 83 MAPKKKs in the potato genome were identified by comparative genomics analysis and named following the ...
The mitogen-activated protein kinase (MAPK) superfamily includes three major subfamilies: extracellular signal-regulated kinase (Erks), c-Jun-N-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs), and p38 kinases (1–3). Activation of MAPK requires the phosphorylation of both tyrosine...
As a result, protein kinases have emerged as important new drug targets for small molecule therapeutics. The mitogen-activated protein kinase (MAPK) signaling pathway transmits signals from the cell membrane to the nucleus in response to a variety of different stimuli. Because this pathway controls...
p38 mitogen-activated protein kinase (MAPK) is thought to play a central role in acute and chronic inflammatory responses. Whether p38MAPK plays a pathogenic role in crescentic GN (GN) and which of its four isoforms is preferentially involved in kidney inflammation is not definitely known. We th...
The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups, the p38 group of MAP kinases, serve as a nexus for signal transduction and play a vital role in numerous biolo...
44, No. 5, 356-362, May 2012 The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer Fang-Ming Chen1,2,3*, Hsueh-Wei Chang2,4*, Sheau-Fang Yang5,6, Ya-Fang Huang2, Pei-Yung Nien2, Yao-Tsung Yeh7,10 ...
Background: The mitogen-activated protein kinase (MAPK) pathway contributes in regulation of many cellular functions such as cell proliferation and differentiation, mobility and apoptosis. This pathway is itself regulated by several outside signals as well as lateral signals from other pathways which co...
Phorbol ester tumor promoters, such as phorbol 12-myristate 13-acetate (PMA), are potent activators of extracellular signal-regulated kinase 2 (ERK2), stress-activated protein kinase (SAPK), and p38 mitogen-activated protein kinase (MAPK) in U937 human leukemic cells. These kinases are regulated...
The mitogen-activated protein kinase (MAPK) pathway, classically associated with cell growth and dependent on tyrosine kinases such as MAPK kinase (MEK), can modulate smooth muscle contractility, and our laboratory has tested the hypothesis that 5-HT can activate the MAPK pathway in arterial smooth...
MAPK: Mitogen-activated protein kinase NSCLC: Non-small cell lung cancer EMT: Epithelial-mesenchymal transition MTC: Medullary thyroid cancer RET: Rearranged during transfection ODAC: Oncology Drug Advisory Committee C-MET: C-mesenchymal-epithelial transition factor ...