The mitogen-activated protein kinase (MAPK) cascade pathway mediates various signalling pathways associated with abiotic stress tolerance in plants. In this research, 15 MAPKs, 5 MAPKKs and 83 MAPKKKs in the potato genome were identified by comparative genomics analysis and named following the ...
The mitogen-activated protein kinase (MAPK) family is a group of serine/threonine kinases that mediate intracellular signaling. The MAPK pathways are activated by diverse extracellular and intracellular stimuli including peptide growth factors, cytokines, hormones, and various cellular stressors such as o...
mitogen-activated protein kinase; ERK extracellular regulated protein kinase; JNK c-Jun NH2-terminal kinase; MEK MAPK/ERK kinase; MKK MAPK kinase; SEK1 stress-activated protein kinase/ERK kinase; JNKK JNK kinase; MEKK MAPK/ERK kinase kinase; TAK transforming growth factor-β-activated kinase; p9...
p38 mitogen-activated protein kinase (MAPK) is thought to play a central role in acute and chronic inflammatory responses. Whether p38MAPK plays a pathogenic role in crescentic GN (GN) and which of its four isoforms is preferentially involved in kidney inflammation is not definitely known. We th...
44, No. 5, 356-362, May 2012 The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer Fang-Ming Chen1,2,3*, Hsueh-Wei Chang2,4*, Sheau-Fang Yang5,6, Ya-Fang Huang2, Pei-Yung Nien2, Yao-Tsung Yeh7,10 ...
The mitogen-activated protein kinase (MAPK) signaling pathway is a series of highly conserved enzymatic reaction cascades involved in various physiological activities including cell proliferation, differentiation, and apoptosis. In glioma, circ-MAPK4 affects cell proliferation and apoptosis by functioning as...
The mitogen-activated protein kinase (MAPK) is known to be involved in the differentiation of various types of cells. To understand the role of p44/42 MAPK (ERK1/2) in astrocyte differentiation, we investigated the effects of U0126 and PD98059, specific inhibitors of the MAPK-activating enzym...
The mitogen-activated protein kinase (MAPK) pathways are known to be involved in various processes of growth, differentiation and cell death. In spite of their ubiquitous presence and seemingly enormous cross-talk with each other, their action is very specific. This review deals with various aspect...
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved series of three protein kinases implicated in diverse biological processes. Here we demonstrate that the cascade arrangement has unexpected consequences for the dynamics of MAPK signaling. We solved the rate equations for the cas...
The mitogen-activated protein kinase/extracellular-signal regulated kinase (MAPK/ERK) cascade is an important contributor to synaptic plasticity that underlies learning and memory. ERK activation by the MAPK/ERK kinase (MEK) leading to cyclic-AMP response element binding protein (CREB) phosphorylation ...