The mitogen-activated protein kinases are a major family of signaling pathways that relay extracellular signals to various destinations throughout the cell and play important roles in normal tissue function and the pathogenesis of a variety of diseases....
Mitogen-activated protein kinases are activated by a kinase cascade composed of three families of protein kinases acting in series. Each MAPK is activated by an upstream MAPK kinase (MAPKK), which, in turn, is activated by a MAPK kinase kinase (MAPKKK). All MAPKKs are dual-specificity ...
mitogen-activated protein kinases(MAPK),是一类进化保守的丝/苏氨酸蛋白激酶,它们会被一系列细胞外的刺激信号激活并介导信号从细胞膜向细胞核传导包括肽生长因子、细胞因子、激素和各种细胞应激物。大豆胞囊线虫(SCN;Heterodera glycines Ichinohe)是最具破坏性的大豆(Glycine max)病原体之一,会给大豆造成严重减产。线...
Map kinaseArabidopsis-thalianaDiseaseresistanceCell-divisionGenesStressTobaccoPhosphorylationMitogen-activated protein kinase.(MAPK) cascades are universal signal transduction modules in eukaryotes, including yeasts, animals and plants. These protein phosphorylation cascades link extracellular stimuli to a wide range...
The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins Activation of the c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is mediated by a protein kinase cascade. This signalin... J Yasuda,AJ Whitmarsh,J Cavanagh,... - 《Molecular & Cellular...
The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins Activation of the c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is mediated by a protein kinase cascade. This signalin... J Yasuda,AJ Whitmarsh,J Cavanagh,... - 《Molecular & Cellular...
Caffeic acid (CA), one of the active constituents of Radix Salvia miltiorrhizae, exhibits antioxidant and anti-inflammatory activities. However, few studies have assessed the ability of CA to inhibit platelet mediated thrombus generation in vivo. In this
belongtotheMEKK/Ste11subfamily of the MAP3K family of enzymes [29]; <9> the enzyme belongs to the MEK family [30]; <7> the enzyme belongs to the MLK family of mitogen activated protein kinase kinase kinases [26]) [26, 28, 29, 30] ...
MAP kinase is the generic term used to describe a family of serine/threonine kinases. MAP kinases, also referred to as extracellular signal-regulated protein kinases or ERKs, are the terminal enzymes in a three-kinase cascade. The reiteration of three-kinase cascades for related but distinct ...
Induction of the mitogen-activated protein kinase phosphatase MKP3 by nerve growth factor in differentiating PC12 In PC12 sympathetic neurons activation and nuclear translocation of family MAP kinases plays an essential role in processes underlying nerve growth factor ... M Camps,C Chabert,M Muda,....