All function in cascades that include at least three tiers of protein kinases. Selective kinase inhibitors have been developed; they are powerful tools to study the physiologic functions of MAPKs and, in some cases, are promising and effective drugs. In this article, the regulation of the three...
Over-expression of the ϵ isoform of protein kinase C did not alter the effect of either PMA or insulin on the activation of MAP kinase and p90 rsk . The results suggest that protein kinase C isotypes α, β I and γ, but not ϵ, can mediate MAP kinase activation by PMA, and ...
The contribution of reactive oxygen species and p38 mitogen‐activated protein kinase to myofilament oxidation and progression of heart failure in rabbits . Br J Pharmacol . 2010; 160 :1408-1416 [ PMC free article ] [ PubMed ]Heusch P, Canton M, Aker S, van de Sand A, Konietzka I, ...
A mitogen-activated protein kinase NtMPK4 activated by SIPKK is required for jasmonic acid signaling and involved in ozone tolerance via stomatal movement ... The mitogen-activated protein kinase (MAPK) cascade is involved in responses to biotic and abiotic stress in plants. In this study, we ...
Distinct roles for mitogen 鈥 activated protein kinase phosphatase 鈥 1 ( MKP 鈥 1 ) and ERK 鈥 MAPK in PTH1R signaling during osteoblast proliferation and differentiation . Parathyroid hormone upregulates BMP 鈥 2 mRNA expression through mevalonate kinase and...
STC2 upregulated Bax and cleaved PARP protein expression in two types of breast cancer cells. In addition, STC2 promoted E-cadherin expression; inhibited vimentin expression; upregulated the phosphorylation levels of the mitogen-activated protein kinase (MAPK) signalling pathway-related proteins p38, ...
RR significantly modulated mitogen-activated protein kinase signaling, activator protein AP-1 signaling, and nuclear factor kappa B (NF-κB) mediated transcription of inflammatory proteins via inhibition of NF-κB translocation, IkB phosphorylation, and proinflammatory cytokine productions such as interleukin...
Summary This chapter contains sections titled: Mitogen-activated protein kinase cascades are evolutionarily conserved signaling modules in eukaryotic cells History of plant MAPK research Plant MAPK cascades Negative regulation of plant MAPK cascades Important tools/techniques in MAPK research Biological functions...
The Mitogen-Activated Protein (MAP) kinase ERK induces tRNA synthesis by phosphorylating TFIIIB. EMBO J. 2003; 22 :2422–2432.Felton-Edkins ZA, Fairley JA, Graham EL, Johnston IM, White RJ, Scott PH. The mitogen-activated protein (MAP) kinase ERK induces tRNA synthesis ...
The mitogen-activated protein kinase (MAPK) cascade acts as a focal point for signal transduction following activation of both G-protein-linked and tyrosine kinase growth factor receptors. A common intermediate between both of these diverse receptor subtypes includes the small guanosine triphosphate (...