The mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) belongs to the MAPK cascades which are central to cell proliferation and apoptosis. The carcinogenic role of MKP-1 has been reported in many type
Protein kinase C μMitogen-activated protein kinasep42Serum response elementHere we show that human protein kinase C μ (PKCμ) activates the mitogen-activated protein kinase (MAPK). Transient expression of constitutive active PKCμ leads to an activation of Raf-1 kinase as demonstrated by in ...
The mitogen-activated protein kinase (MAPK) signaling pathway transmits signals from the cell membrane to the nucleus in response to a variety of different stimuli. Because this pathway controls a broad spectrum of cellular processes, including growth, inflammation, and stress responses, it is ...
MAPK mitogen-activated protein kinase TUNEL terminal deoxynucleotidyl transferase dUTP nicked end-labeling UVR ultraviolet radiation Ultraviolet radiation (UVR) is a potent damaging agent that continuously challenges the epidermis. UVB radiation in particular constitutes the major contributor to many adverse cu...
The mitogen-activated protein kinase (MAPK) superfamily includes three major subfamilies: extracellular signal-regulated kinase (Erks), c-Jun-N-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs), and p38 kinases (1–3). Activation of MAPK requires the phosphorylation of both tyrosine...
The mitogen-activated protein kinase (MAPK) signaling pathway is a series of highly conserved enzymatic reaction cascades involved in various physiological activities including cell proliferation, differentiation, and apoptosis. In glioma, circ-MAPK4 affects cell proliferation and apoptosis by functioning as...
Using the yeast two-hybrid system to screen a human aorta cDNA library, we identified mitogen-activated protein/extracellular signal-responsive kinase (ERK) kinase (MEK)2, a member of the ERK cascade, as an hDlg binding partner. Site-directed mutagenesis showed a major involvement of the PSD-...
Aksan I, Kurnaz ML (2003) A computer-based model for the regulation of mitogen activated protein kinase (MAPK) activation. J Recept Signal Transduct Res 23(2–3):197–209AKSANI and KURNAZ M L. A computer-based model for the regulation of mitogen activated protein kinase (MAPK) activation...
Gene expression profiling of the Δhog1 deletion mutant indicated an involvement of the mitogen activated protein (MAP) kinase Hog1p. However, the function of Hog1p in the response of C. albicans to iron availability was not studied in detail. Thus, we analyzed phenotypic and molecular ...
Mitogen-activated protein (MAP)1 kinases play a key role in transducing various extracellular signals to the nucleus (1). The MAP kinases (MAPKs) consist of three major subgroups that include the ERK, SAPK/JNK, and p38 MAPK families (2). The ERKs, SAPKs, and p38 MAPK are activated by...