The mitochondrial p53 pathwayAngelina V. VasevaUte M. MollBiochimica et Biophysica Acta (BBA) - Bioenergetics
Hypoxia death stimulus induces translocation of p53 protein to mitochondria. Detection by immunofluorescence on whole cells. FEBS Lett. 488: 110–115. CAS Google Scholar MollUM, Zaika A (2001). Nuclearand mitochondrialapoptotic pathways of p53. FEBS Lett. 493: 65–69. Google Scholar Momand ...
The p53 tumor suppressor protein induces apoptosis in response to genotoxic and environmental stress. Recent studies have revealed the existence of a transcription-independent mitochondrial p53 apoptosis pathway, however the mechanism regulating p53 translocation to mitochondria and subsequent initiation of ...
p53Pin1RITAapoptosismitochondriaubiquitinationIn response to intense stress, the tumor protein p53 (p53) tumor suppressor rapidly mounts a direct mitochondrial death program that precedes transcription-mediated apoptosis. By eliminating severely damaged cells, this pathway contributes to tumor suppression as ...
Because Fe-S proteins that contain an Fe-S cluster exhibit diverse biochemical properties in the mitochondrial respiratory chain and enzyme activity17, the Fe-S cluster is an essential cofactor for all living organisms. Defects in ISCU function cause ISCU myopathy, which is characterized by exercise...
The p53 pathway is composed of hundreds of genes and their products that respond to a wide variety of stress signals. These responses to stress include apoptosis, cellular senescence or cell cycle arrest. In addition the p53-regulated genes produce prote
Moll The mitochondrial p53 pathway Biochim. Biophys. Acta, 1787 (2009), pp. 414-420 View PDFView articleView in ScopusGoogle Scholar [77] S.P. Cregan, A. Fortin, J.G. MacLaurin, S.M. Callaghan, F. Cecconi, S.W. Yu, T.M. Dawson, V.L. Dawson, D.S. Park, G. Kroemer, R....
首先,放疗促进细胞核中双链DNA(double-stranded DNA,dsDNA)的释放,增加线粒体外膜的通透性,并且触发细胞质中线粒体DNA(mitochondrial DNA,mtDNA)的暴露,dsDNA与mtDNA均是启动cGAS-STING通路以及随后Ⅰ型干扰素转录的有效介质,随后,Ⅰ型干扰素信号在激活DC中有着至关重要的作用,DC被活化成熟后能够将抗原呈递至T淋巴...
Hyaluronan suppresses lidocaine-induced apoptosis of human chondrocytes in vitro by inhibiting the p53-dependent mitochondrial apoptotic pathway. Acta Pharmacol Sin 2016;37:664-673.Hyaluronan Suppresses Lidocaine-Induced Apoptosis of Human Chondrocytes in Vitro by Inhibiting the P53-Dependent Mitochondrial ...
The mitochondrial p53 pathway. Biochim Biophys Acta 2009;1787:414–20. Article CAS Google Scholar Parrales A, Iwakuma T. Targeting oncogenic mutant p53 for cancer therapy. Front Oncol 2015;5:288. Article Google Scholar Muller PA, Vousden KH. p53 mutations in cancer. Nat Cell Biol 2013;15...