The p53 gene plays a critical role in the DNA damage response pathway, which is responsible for detecting and repairing DNA damage. When DNA is damaged, the p53 protein is activated and induces a variety of cellular responses, including cell cycle arrest, DNA repair, and apoptosis. p53 is a...
One DNA repair pathway, nucleotide excision repair (NER), has been well-documented to be regulated by p53. It seemed probable that p53 may affect other DNA repair pathways. We employed matched isogenic pairs of cell lines, wild-type or p53-deficient, to investigate this question using methyl ...
Depletion of p53 from the nuclear extracts abolished this enhanced activity. Together, this suggests that p53 is involved in more than one DNA repair pathway. 展开 关键词: p53 Temperature-sensitive mutant DNA repair Base excision repair DOI: 10.1016/S0014-5793(99)00505-0 被引量: 276 ...
Mitigating Therapy-Related Myeloid Neoplasia in p53-Mutant Clones through Targeted DNA Repair Pathway Inhibition with PARP Inhibitors Therapy-related myeloid neoplasms (t-MNs), especially therapy-related acute myeloid leukemias (t-AML), pose a severe risk among cancer survivors, notably those treated ...
DNA repair, cell apoptosis, autophagy, and metabolism,1,5,6and determines whether cells die under stress conditions. Over the years, a growing number of studies have revealed the complexity and connectivity of the p53 pathway and by extension its role in metabolic homeostasis, immune microenvironmen...
32 It appears that p53 activities associated with DNA repair contribute to the overall survival potential and drug resistance. Supporting the notion, there is evidence that chemoresistance mediated by p53 in glioma relies at least in part on the ability of p53 to activate the transcription of DNA...
p53可以被大量细胞内/外刺激和压力(stresses,包括DNA damage, oncogene activation, ribosomal or telomere-associated stresses, andnutrient deprivation等)所诱导,作为转录因子调节多种多样下游基因的表达,在细胞和机体层面产生多种效果(cell cycle arrest, DNA repair, senescence,apoptosis, and ferroptosis等),从而帮助...
由于氧化磷酸化是导致基因组DNA损伤的主要氧化应激来源,P53依赖的氧化磷酸化抑制将有助于P53依赖的维持正常细胞(如肝细胞)中氧化磷酸化活性的基因组稳定性。 此外,WTp53的这种代谢作用可能对维持成年干细胞的遗传稳定性和动态平衡很重要,从而延长p53活性适度升高的小鼠的寿命。因此,WTp53的这种代谢作用可能会对正常细...
p53可以被大量细胞内/外刺激和压力 (stresses,包括DNA damage, oncogene activation, ribosomal or telomere-associated stresses, andnutrient deprivation等) 所诱导,作为转录因子调节多种多样下游基因的表达,在细胞和机体层面产生多种效果 (cell cycle arrest, DNA repair, senescence,apoptosis, and ferroptosis等) ,...
p53蛋白是一种抑制细胞增殖或者诱导细胞凋亡或衰老的高度调节蛋白,对各种细胞应激做出应答,包括DNA损伤,氧化应激,缺氧,和致癌信号。在没有应激的正常细胞中,p53蛋白的水平和活性都非常低。当细胞受到刺激,p53蛋白的水平增加,p53的转录活性被激活。p53活性有可能阶段性的进行调节,p53的不同活性,无疑是通过不同的修饰...