p53 in the DNA-damage-repair process. Cold Spring Harb. Perspect. Med. https://doi.org/10.1101/cshperspect.a026070 (2016). Article PubMed PubMed Central Google Scholar Shiloh, Y. & Ziv, Y. The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more. Nat. ...
p53: DNA damage, DNA repair, and apoptosis. Rev Physiol Biochem Pharmacol. 1995;127: 65-95.Götz, C, Montenarh, M (1995) p53: DNA-damage, DNA repair and apoptosis. Rev Physiol Biochem Pharmacol 127: pp. 65-95Gotz et al, " p53: DNA damage, DNA repair, and apoptosis " Rev. ...
Once cellular DNA damage occurs, the DDR is activated to protect damaged DNA integrity. The cell cycle is paused to provide cells an opportunity to activate DNA repair mechanisms. When the DNA damage is severe, cell death programs are activated. Dashed arrows indicate altered mechanisms. Alteration...
This then leads to the activation of a number of genes whose products trigger cell-cycle arrest, apoptosis, or DNA repair. Recent work has suggested that this regulation is brought about largely through DNA damage triggering a series of phosphorylation, de-phosphorylation and acetylation events on ...
The chapter focuses on p53 —that is, a cell cycle regulator activated by deoxyribonucleic acid (DNA) damage. Mutations in the p53 tumor-suppressor gene occur at high frequency in a large variety of human tumors. These mutations include deletions of the entire gene, leading to complete loss of...
N. (2012). ATM phosphorylation of Mdm2 Ser394 regulates the amplitude and duration of the DNA damage response in mice. Cancer Cell, 21(5), 668–679. https://doi.org/10.1016/j.ccr.2012.04.011 Article CAS PubMed PubMed Central Google Scholar Gavin, J. M., Chen, J. J., Liao, H...
英文名称: p53 and DNA-Damage Regulated 1 Human Recombinant 总访问: 249 国产/进口: 进口 半年访问: 21 产地/品牌: prospec 产品类别: 细胞生物学试剂 规格: PRO-007 最后更新: 2024-12-5 货号: CAS 号: 参考报价: 询价 立即询价 电话咨询 ...
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage The p53 tumor-suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. This process is ... R Khosravi,R Maya,T Gottlieb,... - 《...
Stabilization of p53 protein is a key step in the cellular response to DNA damage. A new study describes a long noncoding RNA, DINO, transcribed from the CDKN1A promoter region that induces stabilization of p53 protein and promotes efficient activation of p53 target genes in response to DNA dam...
During this same period, <1% of prostatic glandular cells enter the S phase of the cell cycle, documenting that >95% of these die in G0. During the programmed death of these G0glandular cells, a futile DNA repair process is induced secondary to the DNA fragmentation. This futile DNA ...